Evaluation of Methodology for the Analysis of ‘Time-To-Event’ Data in Pharmacogenomic Genome-Wide Association Studies

Figures & data

Figure 1. Scenario 1 power plots, where the end of study time varied, and with fixed end of study time censoring.

Power is estimated at a 5% significance threshold. Lines with circular points characterize the Cox proportional hazards model and lines with square points the logistic regression model. The color of the line represents the end of study time: 20 days (black); 30 days (red); 40 days (green); 50 days (blue) and 60 days (cyan).

MAF: Minor allele frequency.

Figure 2. Scenario 2 power plot, where the end of study time is fixed at 40 days, but with random censoring during the study period.

Power is estimated at a 5% significance threshold. Lines with circular points characterize the Cox proportional hazards model and lines with square points the logistic regression model. The color of the line corresponds to the rate of censoring defined by the scale parameter of the Weibull distribution: scale 20 (black); scale 40 (red) and scale 60 (green).

MAF: Minor allele frequency.

Figure 3. Scenario 3 power plot, with variable recruitment period, but with fixed end of study time censoring.

Power is estimated at a 5% significance threshold. The recruitment period is between 0 and 10 days. Lines with circular points characterize the Cox proportional hazards model and lines with square points the logistic regression model. The color of the line represents the end of study time: 20 days (black); 30 days (red); 40 days (green); 50 days (blue) and 60 days (cyan).

MAF: Minor allele frequency.

Figure 4. Scenario 4 power plots, where the end of study time varied, and there was random censoring during the study period.

Power is estimated at a 5% significance threshold. Lines with circular points characterize the Cox proportional hazards model and lines with square points the logistic regression model. The color of the line represents the end of study time: 20 days (black); 30 days (red); 40 days (green); 50 days (blue) and 60 days (cyan).

MAF: Minor allele frequency.

Figure 5. Log₁₀ p-value plots for the outcomes time to seizure at 12 months, time to seizure at 24 months and time to seizure 36 months.

Blue lines represent 0.05 significance levels.