Omics Technologies in Personalized Combination Therapy for Cardiovascular Diseases: Challenges and Opportunities

Abstract

The primary purpose of ‘omics’ technologies is to understand the intricacy of genomics, proteomics, metabolomics and other molecular mechanisms to reveal the complex traits of human diseases. The significant use of omics technologies and their applications in medicine gear up the study of the pathogenesis of several disorders. The detection of biomarkers in the early onset of diseases is challenging; still, omics can discover novel molecular mechanisms and biomarkers. In this review, the different types of omics and their technologies are explicated and aimed to provide their emerging applications in cardiovascular precision medicine. These technologies significantly impact optimizing medical treatment for individuals to reach a higher level in precision medicine.

Keywords::

• atherosclerosis
• atrial fibrillation
• biomarkers
• cardiovascular disease
• heart failure
• omics technologies
• precision medicine

Author contributions

Work and concept were initiated by PS Rai; literature search and manuscript writing, tables and figures by S Banerjee and BN Prabhu; PS Rai critically reviewed the manuscript.

Financial & competing interests disclosure

This study was supported by Indian Council of Medical Research (ICMR) (grant no. 2020-6122/CMB-BMS) and Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.