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Research Article

Localized Peripheral Neuropathic Pain: Topical Treatment with Lidocaine 700 mg Medicated Plaster in Routine Clinical Practice

ORCID Icon, , , & ORCID Icon
Pages 521-533 | Received 28 Nov 2021, Accepted 22 Dec 2021, Published online: 10 Jan 2022

Figures & data

Table 1. Baseline characteristics of all patients with localized neuropathic pain conditions (n = 3081 in each group).

Table 2. Baseline characteristics of all patients with localized neuropathic pain conditions treated with the lidocaine 700 mg medicated plaster stratified for patients with postherpetic neuralgia (PHN) and patients with diabetic polyneuropathy, postsurgical neuropathy or other peripheral localized neuropathic pain conditions (l-PNP other than PHN).

Table 3. Main reasons for discontinuation from treatment.

Table 4. Oral recommended first-line medications documented for the treatment of localized neuropathic pain conditions in the OM group after switching from previous medication (n = 3081).

Table 5. Change in concomitant analgesic medication at end of observation.

Table 6. Absolute mean change from baseline (standard error) in average 24-h pain intensity index (averaged over 4, 12 and 24 weeks after treatment initiation).

Table 7. Absolute mean change from baseline (standard deviation) in average 24-h pain intensity index over the observation period in the overall localized peripheral neuropathic pain population.

Table 8. Proportion of patients in the overall localized peripheral neuropathic pain population with a treatment response (≥30% and ≥50% reduction in the average 24-h pain intensity index) over the observation period.

Table 9. Mean change from baseline (standard error) in further effectiveness parameters in the overall localized peripheral neuropathic pain population (averaged over 4, 12 and 24 weeks after treatment initiation).

Figure 1. Patient Global Impression of Change after 24 weeks of treatment.

All patients above the dashed line reported improvement. p < 0.001 in favor of lidocaine 700 mg medicated plaster.

Figure 1. Patient Global Impression of Change after 24 weeks of treatment.All patients above the dashed line reported improvement. p < 0.001 in favor of lidocaine 700 mg medicated plaster.
Figure 2. Drug-related adverse events over the observation period.
Figure 2. Drug-related adverse events over the observation period.

Table 10. All drug-related adverse events documented in patients receiving lidocaine 700 mg medicated plaster during the observation period (n = 3081).

Table 11. Main drug-related adverse events documented in patients receiving oral first-line medication during the observation period (n = 3081).