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Regenerative Medicine Volume 17, 2022 - Issue 12
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Research Article

Platelet-Derived Growth Factors from a Single Donor by Apheresis and One Freeze–Thaw Cycle for Treating Medication-Related Osteonecrosis of the Jaw

Julia Vidán-Estévez1 Transfusion, Hematology & Hemotherapy Unit, Complejo Asistencial Universitario de León (CAULE), León, 24071, Spain
,
Fernando Escalante-Barrigón1 Transfusion, Hematology & Hemotherapy Unit, Complejo Asistencial Universitario de León (CAULE), León, 24071, Spain
,
Sergio Sánchez-Herráez2 Department of Traumatology & Orthopedic Surgery, Complejo Asistencial Universitario de León (CAULE), León, 24071, Spain
&
Jesús Seco-Calvo3 Department of Physical Therapy, Institute of Biomedicine (IBIOMED), University of León, León, 24071, Spain;4 Visiting Professor & Researcher of Department of Physiology, University of the Basque Country, Leioa, 48940, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7818-9777
ORCID Icon
Pages 915-929 | Received 27 Jul 2022, Accepted 12 Sep 2022, Published online: 28 Sep 2022

Figures & data

Table 1. Descriptive analysis of the patients.

Table 2. Descriptive analysis of the wounds.

Figure 1. Clinical image.

Example of a case of medication-related osteonecrosis of the jaw treated with allogeneic platelet-rich plasma. Left: Before al-PRP treatment (baseline). Right: Control after 7 weeks of treatment.

Figure 1. Clinical image.Example of a case of medication-related osteonecrosis of the jaw treated with allogeneic platelet-rich plasma. Left: Before al-PRP treatment (baseline). Right: Control after 7 weeks of treatment.
Figure 2. Radiological images of a 68-year-old male patient.

Total weeks of allogeneic platelet-rich plasma treatment = 14. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 15 months from baseline. (3) Radiographic control at 15 months from baseline. (4) Radiographic control at 17 months from baseline.

Figure 2. Radiological images of a 68-year-old male patient.Total weeks of allogeneic platelet-rich plasma treatment = 14. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 15 months from baseline. (3) Radiographic control at 15 months from baseline. (4) Radiographic control at 17 months from baseline.
Figure 3. Radiological images of an 87-year-old male patient.

Total weeks of allogeneic platelet-rich plasma treatment = 6. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 5 months from baseline. (3) Radiographic control at 8 months from baseline.

Figure 3. Radiological images of an 87-year-old male patient.Total weeks of allogeneic platelet-rich plasma treatment = 6. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 5 months from baseline. (3) Radiographic control at 8 months from baseline.
Figure 4. Radiological images of an 86-year-old male patient.

Total weeks of allogeneic platelet-rich plasma treatment = 13. Partial healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 9 months from baseline.

Figure 4. Radiological images of an 86-year-old male patient.Total weeks of allogeneic platelet-rich plasma treatment = 13. Partial healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 9 months from baseline.
Figure 5. Radiological images of a 66-year-old female patient.

Total weeks of allogeneic platelet-rich plasma treatment = 7. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 10 months from baseline.

Figure 5. Radiological images of a 66-year-old female patient.Total weeks of allogeneic platelet-rich plasma treatment = 7. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 10 months from baseline.
Figure 6. Radiological images of an 87-year-old male patient.

Total weeks of allogeneic platelet-rich plasma treatment = 7. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 6 months from baseline. (3) Radiographic control at 21 months from baseline.

Figure 6. Radiological images of an 87-year-old male patient.Total weeks of allogeneic platelet-rich plasma treatment = 7. Complete wound healing. (1) Radiological image pre-treatment (baseline). (2) Radiographic control at 6 months from baseline. (3) Radiographic control at 21 months from baseline.

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