Regional adiposity distribution and insulin resistance in young Chinese and European Australian women

Abstract

Objective: Lower than normal leg fat mass and excessive trunk fat mass are predictive of insulin resistance (IR) in obese women of European descent. Whether this regional adiposity relationship applies to moderately overweight women of Chinese descent is undetermined. Thus, the relationship between leg and trunk fat mass and IR of young (22.3 ± 0.3 years) sedentary Australian women of either Chinese (CW; n = 22) or European (EW; n = 36) descent was examined. Material and methods: Subjects underwent a maximal oxygen uptake test, blood draw, and dual energy x-ray absorptiometry to measure body composition. Fasting insulin levels and C-reactive protein (CRP) were assessed by ELISA and IR was calculated by HOMA-IR. Blood lipids and glucose were quantified by an automated enzymatic method (Cholestech LDX, USA). Results: Total, arm, trunk, and leg fat was significantly greater (p < 0.05) for the EW group, whereas IR was significantly higher for CW. Fasting lipids and glucose were within normal levels for both groups, whereas CRP levels were significantly higher in EW. For EW trunk fat mass was the only variable significantly correlated with IR (r = 0.40, p < 0.05). In contrast, for CW leg fat mass was significantly correlated with IR (r = − 0.49, p < 0.05). Conclusions: Greater trunk fat mass was associated with higher IR of Australian women of European descent, whereas smaller leg fat mass was associated with higher IR of women of Chinese descent.

Key Words::

• Insulin resistance
• body fat distribution
• ethnicity

Acknowledgements

We would like to thank Winnie Siu, Jennifer Mann, and Darren Irving for help with data collection and Francis Hui for help with the statistical analysis.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.