Metabolism and biomarkers of Vitamin D

Figures & data

Figure 1. Vitamin D Metabolism and Some Physiological Actions. Current knowledge of the cytochrome 450P-containing enzymes in the activation and inactivation of vitamin D together with some information about the physiological actions and regulation of levels of 1α,25(OH)₂D3. Reproduced with permission from NEJM [24].

Figure 2. Hydroxylation steps and structures of vitamin D metabolites. Sites of hydroxylation steps carried out by cytochrome 450P-containing enzymes in the activation and inactivation of vitamin D including the two potential catabolic products of the hormone 1α,25(OH)₂D3 produced by CYP24A1. Reproduced with permission from ABB [22].

Schlingmann KP, Kaufmann M, Weber S, Irwin A, Goos C, Wassmuth A, John U, Misselwitz J, Klaus G, Kuwertz-Broking E, Fehrenbach H, Wingen AM, Guran T, Akcay T, Hoenderop JG, Bindels RJ, Prosser DE, Jones G, Konrad M. Mutations of CYP24A1 and Idiopathic Infantile Hypercalcemia. New Engl J Med 2011;365: 410–421.

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Jones G, Prosser DE, Kaufmann M. 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys, epub Nov 12, 2011.

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