Figures & data
Table 1. Clinical characteristics of the study cohort.
Figure 1. LYPLAL1 and hunger sensations. Two of the presurgical-assessed factor scores (Hunger, Disinhibition) evaluated by the Three Factor Eating Questionnaire are associated with the LYPLAL1 genotype rs4846567. Homozygous SNP carriers showed a 74% lower TFEQ Hunger score (p = 0.018) and 53% lower Disinhibition score (p = 0.038) than GG- and GT-allele carriers. Cognitive restraint increased with 21% but did not withstand multiple testing adjustment. (a) Hunger was first analyzed using an additive genetic effect model. (b) The three factors were further analyzed using a recessive effect model subgrouping patients into G-allele carriers and noncarriers of the G-allele. The figure shows mean scores and standard deviations. All p values were adjusted using Bonferroni correction. *p < 0.05.
Figure 2. LYPLAL1 and excess BMI loss. Rs4846567, close to the Lysophospholipase-like 1 (LYPLAL1) gene, is significantly associated with mean excess BMI loss after RYGB surgery. TT-allele carriers lost 90.0 ± 15% (mean ± SD) of their excess weight two years after RYGB surgery compared to 83.3 ± 18% observed in G-allele carriers (p = 0.031). *p < 0.05.
Figure 3. The TFEQ Hunger score is negatively associated with excess BMI loss (dashed line, β = −2.52; p < 0.001). Patients with the lowest hunger scores (quartile 1, Q1) lost 32% more excess weight compared to individuals with the highest score quartile (Q4, p < 0.001). Patients in Q1 lost 16% more compared to patients in Q3 (p = 0.038). *p < 0.05, **p < 0.01, ***p < 0.001.
