Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

Abstract

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

Keywords::

• Linezolid
• bacterial meningitis
• protein binding ratio
• cerebrospinal fluid

Declaration of interest: Funding was provided by institutional sources only. None of the authors have a conflict of interest to declare.