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Case Reports

Renal transplantation in an HIV-infected patient: Pharmacokinetic aspects

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Pages 216-219 | Received 15 May 2010, Accepted 09 Dec 2010, Published online: 12 Jan 2011
 

Abstract

The introduction of highly active antiretroviral therapy in the mid-1990s led to a dramatic reduction in mortality and progression to AIDS, and human immunodeficiency virus (HIV)infection has now turned into a chronic disease with improved survival and prognosis. Hence, patients with well-controlled HIV infection are no longer prevented from receiving transplants, but treatment must be based on knowledge of pharmacokinetics for the drugs involved. The common approach measuring the cyclosporine level after 2 h or trough level is misleading and it was necessary to determine the area under the curve.

Declaration of interest: Alex Lund Laursen is a member of the GSK advisory board and Kaj Anker Jørgensen is a member of the Astellas advisory board.

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