Figures & data
Figure 1. Changes in ATP/Pi, as measured from 31-P MRS, are temperature dependent. (a) Data from mouse mammary carcinoma grown in the flank measured 18 h after local heating for 15 min at the designated temperature. Figure reproduced with permission from the author and publisher Citation[23]. (b) Data from canine soft tissue sarcomas. Dogs were enrolled on a clinical trial in which hyperthermia was combined with radiation therapy. 31-P MRS studies were performed prior to and 24 h after the first hyperthermia treatment. The change is the difference between these two time points. Data reproduced with permission from the author and publisher Citation[24]. T50 = median temperature. (c) Relationship between change in ATP/PME (pre vs. post first heat treatment) and probability for pathologic CR in human high grade soft tissue sarcomas, based on change in signal between the pre-treatment study and a study performed 24 h after the first hyperthermia treatment Citation[24]. Reproduced with permission from the author and publisher. These data are consistent with the concept that a reduction in ATP after hyperthermia treatment is related to cell killing by hyperthermia.
![Figure 1. Changes in ATP/Pi, as measured from 31-P MRS, are temperature dependent. (a) Data from mouse mammary carcinoma grown in the flank measured 18 h after local heating for 15 min at the designated temperature. Figure reproduced with permission from the author and publisher Citation[23]. (b) Data from canine soft tissue sarcomas. Dogs were enrolled on a clinical trial in which hyperthermia was combined with radiation therapy. 31-P MRS studies were performed prior to and 24 h after the first hyperthermia treatment. The change is the difference between these two time points. Data reproduced with permission from the author and publisher Citation[24]. T50 = median temperature. (c) Relationship between change in ATP/PME (pre vs. post first heat treatment) and probability for pathologic CR in human high grade soft tissue sarcomas, based on change in signal between the pre-treatment study and a study performed 24 h after the first hyperthermia treatment Citation[24]. Reproduced with permission from the author and publisher. These data are consistent with the concept that a reduction in ATP after hyperthermia treatment is related to cell killing by hyperthermia.](/cms/asset/1953110b-3841-4337-a37a-b00492d843eb/ihyt_a_428795_f0001_b.gif)
Figure 2. DCE-MRI perfusion patterns in locally advanced breast cancer Citation[26]. Left panel shows a centrifugal pattern, with central contrast medium filling seen in the wash-in and wash-out parameters (top vs. bottom). Right panel is a tumour exhibiting a centripetal pattern. Data reproduced with permission from the publisher and author.
![Figure 2. DCE-MRI perfusion patterns in locally advanced breast cancer Citation[26]. Left panel shows a centrifugal pattern, with central contrast medium filling seen in the wash-in and wash-out parameters (top vs. bottom). Right panel is a tumour exhibiting a centripetal pattern. Data reproduced with permission from the publisher and author.](/cms/asset/9ae04e1b-40e9-4c8e-b3f0-322e1fee66fa/ihyt_a_428795_f0002_b.gif)
Figure 3. Receiver operating curve for prediction of pathological CR rate following thermochemoradiotherapy, using change in FDG PET uptake after two weeks of treatment Citation[28]. The receiver operating curve assesses the true positive rate (Y-axis) as a function of the false positive rate (X-axis). An ideal test would yield a true positive rate of 1, and a false positive rate of 0. Data reproduced with permission from the author and publisher.
![Figure 3. Receiver operating curve for prediction of pathological CR rate following thermochemoradiotherapy, using change in FDG PET uptake after two weeks of treatment Citation[28]. The receiver operating curve assesses the true positive rate (Y-axis) as a function of the false positive rate (X-axis). An ideal test would yield a true positive rate of 1, and a false positive rate of 0. Data reproduced with permission from the author and publisher.](/cms/asset/39495d29-dea4-466a-86ef-aeafa96ea0f4/ihyt_a_428795_f0003_b.gif)
Figure 4. Probability of metastasis-free survival as a function of time for dogs with tumours having extracellular pH > 7 vs. dogs with tumours having extracellular pH < 7 Citation[36]). Dogs with tumours having a more alkaline extracellular pH had longer metastasis-free survival. Figure reproduced with permission from the author and publisher.
![Figure 4. Probability of metastasis-free survival as a function of time for dogs with tumours having extracellular pH > 7 vs. dogs with tumours having extracellular pH < 7 Citation[36]). Dogs with tumours having a more alkaline extracellular pH had longer metastasis-free survival. Figure reproduced with permission from the author and publisher.](/cms/asset/b48bd860-1da5-4fee-bdb9-292d24ce22c8/ihyt_a_428795_f0004_b.gif)
Figure 5. Metastasis-free survival in dogs with tumours dichotomised by contrast medium wash-in rate (a) and contrast medium wash-out rate (b), as determined from DCE-MRI Citation[45]. Metastasis-free survival was longer in dogs with higher wash-in and wash-out values, likely reflecting tumours with better perfusion. The Kaplan Meier curves shown compare the survival for animals, grouped above and below the median for the whole population. Wash-in value is a rate constant derived from the initial slope of the dynamic contrast enhanced image set and is influenced most strongly by the perfusion rate in the tumour Citation[10]. The wash-out value is derived from the terminal slope of the image set and reflects the rate of contrast clearance from the tumour. This is also influenced by perfusion, but is also reflective of the extracellular volume and permeability of the microvasculature. Figure reproduced with permission from the author and publisher.
![Figure 5. Metastasis-free survival in dogs with tumours dichotomised by contrast medium wash-in rate (a) and contrast medium wash-out rate (b), as determined from DCE-MRI Citation[45]. Metastasis-free survival was longer in dogs with higher wash-in and wash-out values, likely reflecting tumours with better perfusion. The Kaplan Meier curves shown compare the survival for animals, grouped above and below the median for the whole population. Wash-in value is a rate constant derived from the initial slope of the dynamic contrast enhanced image set and is influenced most strongly by the perfusion rate in the tumour Citation[10]. The wash-out value is derived from the terminal slope of the image set and reflects the rate of contrast clearance from the tumour. This is also influenced by perfusion, but is also reflective of the extracellular volume and permeability of the microvasculature. Figure reproduced with permission from the author and publisher.](/cms/asset/ef13e251-b2ba-4f7c-89d4-45c51c62112c/ihyt_a_428795_f0005_b.gif)
Figure 6. Haemoglobin saturation is plotted as a function of time after treatment with MTD doxorubicin. The bars represent the mean and standard deviations of the treated (blue) and control (red) groups. The dashed lines show linear regression lines for each group. A significant difference in the longitudinal trend associated with treatment was found using a linear mixed effects model (p < 0.001). Figure reproduced with permission from the author and publisher Citation[51].
![Figure 6. Haemoglobin saturation is plotted as a function of time after treatment with MTD doxorubicin. The bars represent the mean and standard deviations of the treated (blue) and control (red) groups. The dashed lines show linear regression lines for each group. A significant difference in the longitudinal trend associated with treatment was found using a linear mixed effects model (p < 0.001). Figure reproduced with permission from the author and publisher Citation[51].](/cms/asset/26c4406e-fac2-4fad-ba2c-d0068055e099/ihyt_a_428795_f0006_b.gif)