Figure 1. Role of the HSR in breast cancer. Activated nuclear HSF1 is depicted leading to the expression of Hsp27 and Hsp70 that block programmed cell death and Hsp90 that fosters the accumulation of oncoproteins. Oncoproteins may be mutated (oncogeme) or over-expressed [oncogene, oncogene, oncogene]. Apoptosis is inhibited by Hsp27 and Hsp70 in the cytosol or by TRAP-1 and/or mortalin in the mitochondria.
![Figure 1. Role of the HSR in breast cancer. Activated nuclear HSF1 is depicted leading to the expression of Hsp27 and Hsp70 that block programmed cell death and Hsp90 that fosters the accumulation of oncoproteins. Oncoproteins may be mutated (oncogeme) or over-expressed [oncogene, oncogene, oncogene]. Apoptosis is inhibited by Hsp27 and Hsp70 in the cytosol or by TRAP-1 and/or mortalin in the mitochondria.](/cms/asset/4466eee6-69a9-4684-ba0f-e9e564e77a0c/ihyt_a_490254_f0001_b.gif)
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