The regimen of gemcitabine and cisplatin combined with radio frequency hyperthermia for advanced non-small cell lung cancer: A phase II study

Figures & data

Figure 1. The HY7000 external heat system (A) and working procedure (B).

Table I.  Baseline patient characteristics.

Group		A (n = 40)	B (n = 40)
Average age		60.72	58.98
Sex	Male	32	30
	Female	8	10
Pathological categories	Squamous carcinoma	10	8
	Adenocarcinoma	27	30
	Adenosquamous carcinoma	3	2
Stage	Stage IIIb	14	16
	Stage IV	26	24

Table II.  Responses of groups A and B.

Group	n	CR	PR	SD	PD
A	40	1	18	18	3
B	40	0	17	19	4
Total	80	1	35	37	7

P > 0.05.

Table III.  Main toxicities of groups A and B.

	A (n = 40)				B (n = 40)
Toxicity	I	II	III	IV	I	II	III	IV
Haemoglobin	5	6	1	0	7	6	1	0
Neutrophils	14	7	8	0	13	8	9	2
Platelets	8	4	6	0	6	7	2	0
Nausea and vomiting	14	8	2	0	16	6	3	0
Diarrhoea	4	3	2	0	3	2	1	0
Renal function	4	3	1	0	3	2	0	0
Hepatic function	9	3	0	0	12	1	0	0
Constipation	2	0	0	0	2	1	0	0
Macule	0	0	0	0	1	0	0	0
Dyspnoea	0	0	0	0	1	0	0	0

Table IV.  CRB of groups A and B.

Group	n	Effective	Stable	Ineffective	Response rate
A	40	33	5	2	82.5%
B	40	19	16	5	47.5%

P < 0.05.

Table V.  Impact on each component of the CRB index.

	Criteria
Group	Analgesics reduction	Pain easing	PS improving	Weight increasing
A	35	32	34	36
B	23	19	20	21