Human papillomavirus as a target for management, prevention and therapy

Figures & data

Figure 1. ‘Successful’ versus ‘unsuccessful’ T cell responses to HPV infection. The fate of high risk HPV infections depends on the nature of the resulting immunological response. The lack of HPV-specific cytotoxic T cell responses is likely to lead to persistent infection, premalignant disease and ultimately, invasive cancer. Therapeutic vaccines must override ineffectual immunological mechanisms in order to clear established disease, and a knowledge of what factors may be important is critical for therapeutic vaccine design.