Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: A randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia

Figures & data

Table I.  Characteristics of 57 evaluable subjects.

	Number or mean ± SD
Age (years)	52.5 ± 11.1
Pre-radiotherapy treatment
Surgery	56
Chemotherapy	55
Clinical scenario
Initial presentation	49
T1–2, N > 1	25
T3–4, any N	24
Local recurrence, no prior RT	8
Disease at start of RT
No visible disease	56
Macroscopic disease	1
Receptor status
ER−, PR−, HER2neu−	12
ER−, PR−, HER2neu+	6
ER or PR+, HER2neu−	22
ER or PR+, HER2neu+	17
Radiation dose (Gy) to heated and control sectors
<60 Gy (51.8 ± 6.1 Gy)	23
≥60 Gy (62.1 ± 2.4 Gy)	34

SD, standard deviation; RT, radiotherapy; ER, oestrogen receptor; PR, progesterone receptor; HER2neu, human epidermal growth factor receptor 2

Figure 1. Kaplan-Meier curves for overall survival (OS), freedom from disease relapse (NED), and locoregional control (LC) for all subjects.

Figure 2. Kaplan-Meier curves for freedom from grade ≥2 toxicity for heated and unheated control sectors. Separation between the curves was not statistically significant.

Figure 3. Kaplan-Meier curves for freedom from ≥grade 2 toxicity for patients receiving ≥60 Gy (62.1 ± 2.4 Gy) and patients receiving <60 Gy (51.8 ± 6.1 Gy). Radiation dose was at the discretion of the treating physician, but the heated and control sectors always received the same dose. Separation between the curves was not statistically significant.