Impact of hyperthermic isolated limb perfusion on tumour oxygenation in soft tissue sarcoma

Figures & data

Table I.  Patient and tumour characteristics.

N	34
Age (years)	48 (18–82)
Gender
Male	16
Female	18
Localization
Upper extremity	4
Lower extremity	30
Histology
Liposarcoma	9
Synovial sarcoma	8
Sarcoma NOS	7
Fibrosarcoma	3
Leiomyosarcoma	2
Other	5
Grade
1	3
2	12
3	19

Figure 1. Box-and-whisker-plot showing tumour oxygenation (pO₂, mmHg) during ILP. Boxes indicate 25 to 75 percentiles, the central lines represent medians and whiskers display the 1.5 interquartil range. Time points as follows: T1: after establishment of the limb circuit, T2: 5 min. after application of TNF, T3: 5 min. after application of melphalan, T4: 30 min. after administration of melphalan and T5: before wash out.

Figure 2. Box-and-whisker-plot showing muscle and tumour temperature during ILP. Boxes indicate 25 to 75 percentiles, the central lines represent medians and whiskers display the 1.5 interquartil range. Time points as follows: T1: after establishment of the limb circuit, T2: 5 min. after application of TNF, T3: 5 min. after application of melphalan, T4: 30 min. after administration of melphalan and T5: before wash out.

Table II.  Pearson Correlation Coefficients of ILP related factors and tumour necrosis.

Variable 2	Correlation coefficient	p value
Initial tumour pO2	−0.38	0.07
Minimal tumour pO2	−0.33	0.13
Initial tumour temperature	0.50	0.01
Maximal temperature	−0.05	0.97
Temperature increment	−0.34	0.08
Limb circuit haemoglobin	0.09	0.67