Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale

Figures & data

Figure 1. Pristine and spread-out Bragg peaks of proton and ¹²C ion beams showing similar dose profiles except higher beam entrance dose and dose due to fragmentation tail behind the target with ¹²C ions. Reproduced with permission [29].

Figure 2. Survival of asynchronous CHO cells exposed to either 4 MeV X-rays (circles) or ¹²C ions (squares) either at 37 °C (filled circles and squares) or 43 °C (open circles and squares). The marked thermal sensitisation at 43 °C is evident with X-rays while it was minimal with ¹²C ions (black arrow). Reproduced with permission [49].

Figure 3. Proton beam thermo-radiotherapy could yield a summation of the physical dose profiles of protons and the high LET advantages of hyperthermia. Thus, proton beam thermo-radiotherapy could mimic ¹²C ion therapy.

Figure 4. Schematic outline of the ‘HYPROSAR’ protocol.

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