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Research Article

Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale

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Pages 524-530 | Received 11 Jul 2014, Accepted 06 Sep 2014, Published online: 14 Oct 2014

Figures & data

Figure 1. Pristine and spread-out Bragg peaks of proton and 12C ion beams showing similar dose profiles except higher beam entrance dose and dose due to fragmentation tail behind the target with 12C ions. Reproduced with permission [Citation29].

Figure 1. Pristine and spread-out Bragg peaks of proton and 12C ion beams showing similar dose profiles except higher beam entrance dose and dose due to fragmentation tail behind the target with 12C ions. Reproduced with permission [Citation29].

Figure 2. Survival of asynchronous CHO cells exposed to either 4 MeV X-rays (circles) or 12C ions (squares) either at 37 °C (filled circles and squares) or 43 °C (open circles and squares). The marked thermal sensitisation at 43 °C is evident with X-rays while it was minimal with 12C ions (black arrow). Reproduced with permission [Citation49].

Figure 2. Survival of asynchronous CHO cells exposed to either 4 MeV X-rays (circles) or 12C ions (squares) either at 37 °C (filled circles and squares) or 43 °C (open circles and squares). The marked thermal sensitisation at 43 °C is evident with X-rays while it was minimal with 12C ions (black arrow). Reproduced with permission [Citation49].

Figure 3. Proton beam thermo-radiotherapy could yield a summation of the physical dose profiles of protons and the high LET advantages of hyperthermia. Thus, proton beam thermo-radiotherapy could mimic 12C ion therapy.

Figure 3. Proton beam thermo-radiotherapy could yield a summation of the physical dose profiles of protons and the high LET advantages of hyperthermia. Thus, proton beam thermo-radiotherapy could mimic 12C ion therapy.

Figure 4. Schematic outline of the ‘HYPROSAR’ protocol.

Figure 4. Schematic outline of the ‘HYPROSAR’ protocol.

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