Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with carboplatin in the treatment of advanced stage ovarian carcinoma

Figures & data

Figure 1. The Alexis™ ring and the base of the GelPort within the context of the upper abdomen (1), temperature sensors (2), inflow tubing (3), left lower abdomen (4), outflow tubing (5), supra-pubic region (6) and right lower abdomen (7).

Table 1. Demographic and pathological characteristics of the ovarian cancer patients treated with consolidation heated intraperitoneal carboplatin chemotherapy (n = 11).

Demographic	Mean (SD)
Age (years)	63 (6.05)
Height (cm)	160.8 (6.60)
Weight (kg)	75.9 (17.86)
BMI (kg/m^2)	29.4 (6.20)
ECOG performance status (range)	0 (0–1)
Disease stage (n/%)
IIIA	1 (9.1)
IIIB	2 (18.2)
IIIC	7 (63.6)
IV	1 (9.1)
Grade
Poorly differentiated	7 (63.6)
Moderately differentiated	3 (27.3)
Well differentiated	1 (9.1)
Histology
Serous	8 (72.7)
Endometrioid	1 (9.1)
Mucinous	1(9.1)
Clear cell	1 (9.1)

BMI, body mass index; ECOG, Eastern Cooperative Oncology Group.

Figure 2. The patients’ mean composite temperature (°C) throughout the upper-abdomen, mid-abdomen and midline supra-pubic regions.

Figure 3. The patients’ mean composite temperature (°C) for the inflow and outflow tubes.

Table 2. Temperature analyses incorporating the patients’ composite intra-abdominal locations and inflow/outflow tubing values.

Anatomical location	Median (range)	Outlier value/ interquartile range
Right upper abdomen	41.63 (40.7–41.8)	outside value (40.74)/ < lower quartile
Left lower abdomen	41.9 (41.4–42.4)	none
Right lower abdomen	41.3 (40.4–41.5)	far out value (40.39)/< lower quartile
Left lower abdomen	41.3 (40.3–41.6)	outside value (40.31)/ < lower quartile
Supra-pubic region	41.1 (40.4–41.3)	outside value (40.4)/ < lower quartile
Inflow tubing	42.6 (42.5–42.8)	none
Outflow tubing	41.9 (41.2–42.1)	far out value (41.17)/ < lower quartile

Table 3. Temperature analyses in accordance with anatomic location and time interval.

Anatomical location	Time (min)	Median (range)	Outlier value/interquartile range
Right upper abdomen	0	41.6 (38.7–42.8)	none
	15	41.9 (39.5–41.7)	none
	30	41.8 (39.5–42.8)	none
	45	41.6 (40.0–43.0)	none
	60	41.8 (40.8–42.5)	none
	75	41.6 (40.3–42.5)	outside value (40.3, 40.6)/< lower quartile
	90	41.7 (40.2–43.2)	none
Left upper abdomen	0	41.2 (40.4–42.3)	none
	15	42.6 (41.1–43.8)	none
	30	42.4 (40.2–43.2)	none
	45	42.7 (40.6–43.1)	none
	60	42.4 (40.1–43.2)	outside value (40.1)/< lower quartile
	75	42.0 (40.1–42.9)	outside value (40.1, 40.7)/< lower quartile
	90	41.8 (39.5–43.3)	none
Right lower abdomen	0	40.7 (37.5–42.0)	none
	15	41.8 (38.3–42.8)	none
	30	41.6 (38.8–43.1)	none
	45	41.7 (39.6–42.9)	none
	60	41.6 (39.8–43.1)	outside value (39.8)/< lower quartile
			outside value (43.1)/> upper quartile
	75	41.7 (39.0–43.1)	none
	90	41.7 (38.6–42.9)	outside value (38.6)/< lower quartile
Left lower abdomen	0	40.2 (38.3–42.0)	none
	15	41.7 (39.1–42.6)	none
	30	41.4 (39.4–42.3)	none
	45	41.6 (40.1–43.3)	none
	60	41.6 (40.2–43.4)	none
	75	41.3 (39.4–42.6)	none
	90	41.1 (39.0–42.2)	outside value (39.0)/< lower quartile
Supra-pubic region	0	40.2 (39.0–42.2)	none
	15	41.2 (38.6–43.4)	none
	30	41.1 (39.0–42.7)	none
	45	40.9 (39.1–43.3)	outside value (39.1)/< lower quartile
			outside value (43.3)/> upper quartile
	60	40.9 (39.4–42.9)	none
	75	40.9 (39.3–42.4)	none
	90	40.7 (39.3–42.9)	none
Inflow tubing	0	42.3 (41.3–42.6)	none
	15	42.9 (41.5–43.3)	outside value (42.1)/< lower quartile
			far out value (41.5)/< lower quartile
	30	42.7 (41.1–43.5)	outside value (41.1)/< lower quartile
	45	42.8 (41.5–43.2)	outside value (41.5)/< lower quartile
	60	42.8 (41.3–43.2)	far out value (41.3)/< lower quartile
	75	42.9 (41.3–43.2)	outside value (41.3)/< lower quartile
	90	42.7 (41.3–43.1)	outside value (41.3)/< lower quartile
Outflow tubing	0	42.7 (41.8–42.8)	none
	15	42.1 (40.9–42.7)	outside value (40.9)/< lower quartile
	30	41.9 (40.8–42.7)	none
	45	42.1 (41.7–42.3)	none
	60	42.1 (41.7–42.3)	none
	75	42.0 (41.1–42.4)	none
	90	42.0 (41.4–42.4)	none