Figures & data
Figure 1. The effect of OXi4503 (50 mg/kg) and mild temperature hyperthermia (41.5 °C, 60 min) on the radiation response of a C3H mammary carcinoma. (A) Radiation dose response curves for local tumour control in tumours treated with radiation alone (△), OXi4503 injected 1.5 h before irradiating (▴), radiation administered in the middle of heating (○), or the combination of OXi4503, radiation and heat (•). Points are for an average of 10 mice with the lines drawn following logit analysis. (B) The TCD50 doses are a function of time relative to irradiation, and are taken from the curves shown in (A) and for other similar dose–response curves. Results are for radiation alone (
![Figure 1. The effect of OXi4503 (50 mg/kg) and mild temperature hyperthermia (41.5 °C, 60 min) on the radiation response of a C3H mammary carcinoma. (A) Radiation dose response curves for local tumour control in tumours treated with radiation alone (△), OXi4503 injected 1.5 h before irradiating (▴), radiation administered in the middle of heating (○), or the combination of OXi4503, radiation and heat (•). Points are for an average of 10 mice with the lines drawn following logit analysis. (B) The TCD50 doses are a function of time relative to irradiation, and are taken from the curves shown in (A) and for other similar dose–response curves. Results are for radiation alone (Display full size), OXi4503 injected 1.5 h before irradiating (▴), radiation and heat (○), and OXi4503, radiation and heat (•). Radiation was administered at time zero. Points involving radiation and heat are shown at the middle of the 1-h heating period. Errors are 95%CI.](/cms/asset/b15ff086-92eb-4609-9edc-d4bb0a2a5655/ihyt_a_1024289_f0001_b.jpg)
Figure 2. The effect of OXi4503 (50 mg/kg) and mild temperature hyperthermia (41.5 °C, 60 min) on the radiation response of normal foot skin. (A) Radiation dose response curves for moist desquamation in skin treated with radiation alone (△), OXi4503 injected 1.5 h before irradiating (▴), radiation administered in the middle of heating (○), or the combination of OXi4503, radiation and heat (•). Points are for an average of seven mice with the lines drawn following logit analysis. (B) The MDD50 doses are a function of time relative to irradiation, and are taken from the curves shown in (A) and for other similar dose–response curves. Results are for radiation alone (
![Figure 2. The effect of OXi4503 (50 mg/kg) and mild temperature hyperthermia (41.5 °C, 60 min) on the radiation response of normal foot skin. (A) Radiation dose response curves for moist desquamation in skin treated with radiation alone (△), OXi4503 injected 1.5 h before irradiating (▴), radiation administered in the middle of heating (○), or the combination of OXi4503, radiation and heat (•). Points are for an average of seven mice with the lines drawn following logit analysis. (B) The MDD50 doses are a function of time relative to irradiation, and are taken from the curves shown in (A) and for other similar dose–response curves. Results are for radiation alone (Display full size), OXi4503 injected 1.5 h before irradiating (▴), radiation and heat (○), and OXi4503, radiation and heat (•). Radiation was administered at time zero. Points involving radiation and heat are shown at the middle of the 1-h heating period. Errors are 95%CI.](/cms/asset/677238db-45ad-4fe3-88bf-45b33f0dce4a/ihyt_a_1024289_f0002_b.jpg)