Figures & data
Figure 1. Schematic illustration of the interrelationship between tumour cells and their vascular supply. On the left, a functional tumour vessel is shown from which the tumour cells obtain their oxygen and nutrient supply. But, due to diffusion gradients from that vessel, areas develop that contain viable cells that are oxygen deficient, nutrient depleted and highly acidic. A similar arrangement is shown on the right, but here blood flow is transiently stopped and this results in cells being temporarily starved of oxygen and nutrients. Modified from Horsman et al. [Citation12].
![Figure 1. Schematic illustration of the interrelationship between tumour cells and their vascular supply. On the left, a functional tumour vessel is shown from which the tumour cells obtain their oxygen and nutrient supply. But, due to diffusion gradients from that vessel, areas develop that contain viable cells that are oxygen deficient, nutrient depleted and highly acidic. A similar arrangement is shown on the right, but here blood flow is transiently stopped and this results in cells being temporarily starved of oxygen and nutrients. Modified from Horsman et al. [Citation12].](/cms/asset/43cc64ab-4a01-44dc-b320-ff6d699d2f6e/ihyt_a_1099169_f0001_c.jpg)
Table 1. Cell-based approaches with the potential to improve thermoradiotherapy. Agents that have been combined with hyperthermia, radiation or thermoradiation to improve anti-tumour activity are indicated.
Table 2. Vascular-based approaches with the potential to improve thermoradiotherapy. Agents that have been combined with hyperthermia, radiation or thermoradiation to improve anti-tumour activity are indicated.
Figure 2. The effect of a single intraperitoneal injection of nicotinamide (1000 mg/kg) and local water bath heating (42.5 °C; 60 min) on the radiation response of foot-implanted C3H mammary carcinomas and normal foot skin. Left panels: Radiation dose response curves for tumour control (top) or moist desquamation in skin (bottom) when treated with radiation alone (Δ), nicotinamide 30 min before irradiating (▴), radiation administered in the middle of heating (○), or the combination of nicotinamide, radiation and heat (•). Points are for an average of 11 mice with the lines drawn following logit analysis. Right panels: TCD50 (top) or MDD50 (bottom) doses (radiation dose producing 50% tumour control or moist desquamation, respectively) as a function of time after irradiating; data are from the curves shown in the left panels, and for other similar dose response curves. Results show radiation alone (
