5-Fluorouracil/Leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma: A clinical experience

Figures & data

Table I. Cycle 1 and cycles 2–10 treatment related toxicities by grade.

		Cycle 1				Cycles 2–10
		Grade				Grade
		1	2	3		1	2	3
		(# of episodes)			Total	(# of episodes)			Total
Blood/Bone Marrow	Neutropenia	2	1		3	1	1		2
Cardiovascular (arrythmia)	QTc prolongation							1	1
Constitutional symptoms	Abdominal pain	1			1	1	1		2
	Fatigue	4			4	3	1		4
	Weight gain		1		1	5	1		6
Gastrointestinal	Nausea/vomiting					3	2		5
	Diarrhea	3			3	2	2		4
Lymphatics	Peripheral edema	1	1		2	2	2		4
Total		11	3	0	14	17	10	1	28

Figure 1. Patient 1. PET scan from (A) May 2009 showing a maximum SUV uptake value of 9.28 and (B) June 2010 with a maximum SUV uptake value of 2.12. CT scan from (C) May 2009 and (D) June 2010.

Figure 2. Patient 2. PET scans from (A) February 2010 showing a maximum SUV uptake value of 4.03 and (B) May 2010 with a maximum SUV uptake value of 2.51. CT scan from (C) February 2010 and (D) May 2010.