Monte Carlo calculations of absorbed doses in tumours using a modified MOBY mouse phantom for pre-clinical dosimetry studies

Figures & data

Figure 1. Dorsal view of the generated Moby phantom, showing the four different tumour locations on the left and right flanks and thighs.

Table I. Predominant emissions from isotopes in this study.

Nuclide	Energy (Mev) Max/Mean	type	Yield
^111In	0.245	γ	0.940
	0.171	γ	0.902
	0.145	e^−	0.084
	0.219	e^−	0.050
^125I	0.027^a	X-ray	1.163
	0.031^a	X-ray	0.245
	0.035	γ	0.067
	0.003^a	e^−	2.240
	0.023	e^−	0.197
	0.031^a	e^−	0.155
^131I	0.364	γ	0.812
	0.637	γ	0.073
	0.284	γ	0.061
	0.723	γ	0.018
	0.334/0.097	β^−	0.074
	0.606/0.192	β^−	0.893
^177Lu	0.208	γ	0.110
	0.113	γ	0.064
	0.102	e^−	0.070
	0.176/0.047	β^−	0.123
	0.384/0.111	β^−	0.090
	0.497/0.149	β	0.787
^90Y	2.284/0.935	β^−	1.000

a = weighted values of energies.

Figure 2. Self–absorbed fraction for tumour location 2 (right flank) as a function of energy for different tumour masses, for electrons (A) and photons (B).

Figure 3. The ratio of tumour self–dose to tumour total dose from the radionuclides studied for tumour location 1 (left flank) (A) and tumour location 3 (left thigh) (B), for a cumulated activity concentration ratio tumour:liver:kidney:remainder of 10:10:10:1 in the 34 g mouse phantom.

Figure 4. The ratio of the tumour self–dose to the tumour total dose from the studied radionuclides for tumour location 1 (left flank) (A) and tumour location 3 (left thigh) (B), for a cumulated activity concentration ratio tumour:liver:kidney:remainder of 10:10:10:0 in the 34 g mouse phantom.

Figure 5. The self-dose: total dose ratio from the studied radionuclides for tumour location 1 (left flank) for the three body weights: A = 22 g, B = 28 g and C = 34 g. The cumulated activity concentration ratio tumour:liver:kidney:remainder in A (left) is 10:10:10:1.

Figure 6. The liver self-dose: total liver absorbed dose ratio for the studied radionuclides and tumour at location 1 (left flank) for the 34 g mouse phantom. The cumulated activity concentration ratio tumour: liver is 100:1.