Survival for Ovarian Cancer in Europe: The across-country variation did not shrink in the past decade

Figures & data

Table I. Number of cases, years of diagnosis, quality indicators, cases eligible for survival analysis and age-standardised incidence rates for women with ovarian cancer in 1995–2002, by registry.

Area	Country	Registry	Years of diagnosis	Total malignant cases	Cases with multiple tumours (%)	DCO and autopsy^1 (%)	Cases eligible for survival analysis	Mean number of cases contributing to period analysis^2	MV (%^3)	Censored^4 cases in 1995–1998 (%)	Incidence per 100 000 cases (95% CI)^5
North	Denmark	Denmark	1995–1999	2998	7.7	1.4	2956		94.6	0.5	24.4	(23.5–25.3)
	Finland	Finland	1995–2002*	3799	10.5	3.0	3686	1365	96.9	0.7	18.7	(18.1–19.3)
	Iceland	Iceland	1995–2002*	172	16.3	1.2	170	61	96.5	0.0	20.6	(17.6–24.1)
	Norway	Norway	1995–2002*	3867	10.3	1.0	3829	1453	94.9	0.0	24.0	(23.2–24.8)
	Sweden	Sweden	1995–2002*	6831	10.3	1.9	6700	2491	99.8	0.9	19.9	(19.4–20.4)
UK and	Ireland	Ireland	1995–2002	2453	3.8	3.2	2374	891	89.1	0.4	21.8	(20.9–22.7)
Ireland	England	UK East Anglia	1995–2002*	2536	6.1	1.9	2489	960	88.7	11.7	24.1	(23.2–25.1)
		UK Mersey	1995–1999	1320	5.0	5.4	1249		86.4	0.7	22.7	(21.4–24.0)
		UK North Western	1995–1999	2092	2.5	1.2	2067		84.4	0.0	21.0	(20.0–21.9)
		UK Northern and Yorkshire	1995–2002*	4583	5.9	1.8	4499	1729	88.6	0.0	20.9	(20.3–21.6)
		UK Oxford	1995–2002*	2035	2.9	0.9	2016	754	91.1	0.4	21.7	(20.7–22.7)
		UK South Western	1995–1999	3935	8.0	8.8	3587		77.1	0.4	22.4	(21.7–23.2)
		UK Thames	1995–1999	7300	5.6	14.8	6222		90.0	0.6	23.0	(22.4–23.5)
		UK Trent	1995–1999	2550	6.1	6.2	2391		83.1	0.0	22.0	(21.1–22.9)
		UK West Midlands	1995–2002*	4505	6.8	5.9	4238	1599	89.1	0.0	22.0	(21.3–22.7)
	Northern Ireland	UK Northern Ireland	1995–2002	1271	6.1	1.1	1257	474	85.6	0.3	22.6	(21.3–23.9)
	Scotland	UK Scotland	1995–2002*	4500	9.4	1.1	4451	1668	87.8	0.3	21.6	(20.9–22.3)
	Wales	UK Wales	1995–2002*	2977	9.2	11.9	2624	1005	59.5	0.0	24.5	(23.5–25.4)
Centre	Austria	Austria	1995–2002*	7163	4.9	10.3	6423	2396	92.4	12.9	18.8	(18.1–19.6)
	Belgium	Flemish	1997–2001	2790	1.7	0.2	2785		85.1	1.3	21.9	(21.3–22.4)
	France	Bas Rhin	1995–1997	257	4.7	0.0	257		96.9	1.6	19.9	(17.4–22.6)
		Calvados	1995–1997	146	2.1	0.0	146		98.6	1.4	16.9	(14.1–20.0)
		Doubs	1995–1999	118	1.7	0.0	118		94.9	0.0	18.8	(15.5–22.7)
		Haut Rhin	1995–1997	163	4.9	0.0	163		94.5	0.0	17.8	(15.0–20.8)
		Hérault	1995–1997	167	1.8	0.0	167		0.0	0.0	13.4	(11.4–15.8)
		Isère	1995–1997	209	3.8	0.0	209		91.9	1.0	15.5	(13.4–17.8)
		Manche	1995–1997	138	2.9	0.0	138		99.3	4.3	20.1	(16.6–24.0)
		Somme	1995–1997	127	4.7	0.0	127		92.1	2.4	17.4	(14.4–21.0)
		Tarn	1995–1997	93	7.5	0.0	93		90.3	0.0	16.7	(13.2–20.8)
	Germany	Saarland	1995–2002*	902	7.6	4.1	865	323	93.4	9.3	18.2	(17.0–19.5)
	Netherlands	Amsterdam	1995–2002*	1694	11.7	0.3	1689	621	97.0	0.7	16.9	(16.1–17.8)
		Eindhoven	1995–2001	535	7.9	0.0	535		98.1	0.0	18.2	(16.7–19.9)
		North Netherlands	1995–2001	1140	3.9	0.5	1134		96.3	0.0	17.4	(16.4–18.5)
		Twente	1995–2002	753	3.5	0.3	751	282	96.9	0.0	17.3	(16.1–18.7)
	Switzerland	Basel	1995–2001	242	6.6	0.8	240		99.6	7.6	14.6	(12.7–16.7)
		Geneva	1995–2002*	293	5.5	1.7	288	109	94.8	0.0	17.7	(15.6–19.9)
		St. Gallen	1995–2002*	408	16.7	0.5	406	157	94.3	31.1	21.0	(18.9–23.3)
		Ticino	1995–2002	201	4.0	2.0	197	84	98.0	0.0	17.4	(15.0–20.2)
		Valais	1995–1998	97	5.2	1.0	96		97.9	28.1	20.9	(16.9–25.6)
East	Czech Republic	West Bohemia	1995–2002*	759	6.6	7.4	703	276	92.7	11.4	24.0	(22.2–25.7)
	Poland	Cracow	1995–2002*	806	14.3	0.7	800	307	84.3	4.7	28.9	(26.9–31.0)
		Kielce	1995–2002	781	0.4	0.0	781	305	87.6	0.0	18.6	(17.3–20.0)
		Warsaw	1995–2002*	1345	7.1	1.4	1326	473	88.9	0.7	19.3	(18.3–20.4)
	Slovakia	Slovakia	1995–2002*	3035	4.9	11.2	2695	1003	95.6	0.4	17.3	(16.7–17.9)
South	Italy	Alto Adige	1995–2002	344	3.8	0.6	342	128	91.5	0.6	18.7	(16.7–20.9)
		Biella	1995–2002	148	3.4	2.7	144	55	93.8	0.0	15.6	(12.9–18.6)
		Ferrara	1995–2002*	272	5.9	1.5	268	106	82.8	0.0	14.9	(13.0–17.0)
		Firenze	1995–2002*	993	5.5	0.5	988	364	80.1	1.2	18.4	(17.2–19.6)
		Friuli V.G.	1995–2002	1033	3.2	3.2	1000	378	89.4	0.2	17.7	(16.6–19.0)
		Genova	1995–2000	652	6.6	1.8	640		86.6	0.5	18.3	(16.8–20.0)
		Macerata	1995–1999	154	6.5	0.6	153		86.9	0.0	18.3	(15.3–21.7)
		Modena	1995–2002*	513	6.0	0.8	509	188	84.3	0.0	17.5	(15.9–19.2)
		Napoli	1996–2000	136	0.0	2.2	133		79.7	0.0	13.9	(11.7–16.5)
		Parma	1995–2002*	415	7.2	2.2	406	161	86.7	0.0	20.6	(18.4–22.9)
		Ragusa	1995–2002*	192	8.3	0.5	191	68	81.2	0.0	17.1	(14.7–19.8)
		Reggio Emilia	1995–2002	310	2.3	0.3	309	132	81.6	0.0	17.4	(15.3–19.6)
		Romagna	1995–2002*	821	6.6	2.2	803	300	86.2	0.5	17.6	(16.3–19.0)
		Salerno	1996–2001	470	0.6	1.7	462		78.4	0.0	15.5	(14.1–17.0)
		Sassari	1995–2002	260	3.8	4.2	249	94	86.3	0.0	14.2	(12.5–16.1)
		Torino	1995–2001	726	5.5	2.3	709		89.1	0.0	18.9	(17.5–20.4)
		Trento	1995–2000	292	2.4	2.1	286		81.8	0.0	20.4	(18.0–23.1)
		Umbria	1995–2002	697	5.7	1.1	689	255	79.5	0.0	18.0	(16.6–19.5)
		Varese	1995–1999	400	9.0	1.3	395		89.6	11.3	17.5	(15.7–19.4)
		Veneto	1995–2000	1100	6.3	2.1	1077		86.4	0.0	16.1	(15.1–17.2)
	Malta	Malta	1995–2002	252	1.6	1.6	248	93	92.3	0.9	19.7	(17.3–22.3)
	Portugal	South Portugal	1998–1999	576	4.2	0.0	576		92.2	2.1	12.8	(11.7–13.9)
	Slovenia	Slovenia	1995–2002*	1247	3.2	1.6	1227	459	96.3	0.0	16.8	(15.8–17.7)
	Spain	Basque Country	1995–1999	665	5.9	3.5	642		91.0	0.0	13.2	(12.2–14.3)
		Girona	1995–2002	307	1.6	4.2	294	106	90.8	0.0	14.2	(12.6–16.1)
		Murcia	1995–1998	244	2.5	2.5	238		92.0	2.1	14.1	(12.3–16.1)
		Navarra	1995–1999	194	8.2	1.5	191		91.1	1.4	14.9	(12.7–17.3)
		Tarragona	1995–1999	192	4.7	3.1	186		90.9	0.0	13.8	(11.8–16.0)
Total cases				97 691	6.6	4.5	93 292	23 661	89.4	1.9	20.2	(20.1–20.3)

¹Women diagnosed from the death certificate only (DCO) and incidentally discovered at autopsy (autopsy).

²Mean number of cases contributing to period estimates of five-year relative survival in 2000–2002.

³Proportions were calculated with respect to the number of cases eligible for survival analysis in 1995–2002, MV: microscopically verified cases.

⁴Alive cases with follow-up less than five years.

⁵Incidence is age-standardised with weights of the European standard population truncated to age group 15–99, CI: confidence interval;

*CRs included in time trend survival analyses from the beginning of 1990s.

Table II. Number of cases and distribution (%) of morphological groups for microscopically verified cases diagnosed in 1995–2002 (and 2000–2002) provided by 69¹ CRs, by country.

	No. of cases		serous		mucinous		germ-cell		other tumours		NOS^2
Finland	3571	(1338)	50.5	(52.5)	12.5	(11.4)	2.4	(2.5)	25.4	(24.1)	9.2	(9.5)
Iceland	164	(65)	60.4	(64.6)	7.3	(4.6)	1.8	(1.5)	26.2	(24.6)	4.3	(4.6)
Norway	3635	(1407)	55.5	(54.9)	7.3	(8.2)	1.5	(1.7)	32.4	(32.1)	3.2	(3.1)
Sweden	6685	(2467)	47.9	(48.8)	9.4	(8.1)	1.3	(1.5)	39.7	(40.3)	1.6	(1.3)
Ireland	2116	(812)	45.9	(44.8)	12.2	(11.1)	1.4	(1.1)	34.2	(36.5)	6.2	(6.5)
UK England	19 384	(4756)	42.0	(43.6)	10.4	(8.8)	1.2	(1.2)	39.7	(39.2)	6.7	(7.2)
UK Northern Ireland	1076	(407)	41.3	(47.2)	9.7	(8.4)	1.6	(1.7)	37.5	(32.9)	9.9	(9.8)
UK Scotland	3906	(1415)	41.3	(42.9)	12.1	(8.6)	1.1	(1.0)	40.1	(40.8)	5.4	(6.7)
UK Wales	1562	(700)	38.5	(41.4)	9.3	(9.3)	1.3	(1.3)	37.7	(35.0)	13.2	(13.0)
Austria	5937	(2077)	45.1	(45.1)	7.2	(6.6)	2.0	(1.4)	33.2	(32.4)	12.4	(14.5)
Belgium	2371	(1018)	45.5	(48.7)	9.2	(9.5)	1.5	(1.3)	33.9	(32.7)	9.9	(7.8)
France	1189	(-)	51.3	(-)	13.2	(-)	2.4	(-)	29.8	(-)	3.3	(-)
Germany	808	(318)	53.7	(55.3)	10.4	(10.4)	1.4	(1.6)	23.8	(22.6)	10.8	(10.1)
Netherlands	3984	(1277)	50.5	(50.3)	11.4	(10.1)	1.7	(2.0)	35.8	(37.2)	0.6	(0.5)
Switzerland	1182	(382)	57.4	(57.6)	9.6	(7.3)	1.3	(0.8)	30.4	(33.5)	1.4	(0.8)
Czech Republic	652	(249)	39.3	(34.9)	10.9	(8.8)	1.2	(2.0)	42.0	(48.6)	6.6	(5.6)
Poland	2537	(936)	40.2	(40.7)	7.5	(5.8)	1.7	(1.5)	39.1	(41.5)	11.4	(10.6)
Slovakia	2576	(917)	53.1	(50.5)	13.3	(14.7)	1.9	(1.3)	28.3	(30.8)	3.4	(2.7)
Italy	8303	(2441)	44.2	(44.8)	9.6	(9.5)	1.2	(1.1)	34.9	(34.0)	10.2	(10.5)
Malta	229	(102)	36.7	(42.2)	17.9	(15.7)	3.1	(2.0)	38.4	(38.2)	3.9	(2.0)
Portugal	531	(-)	42.7	(-)	10.9	(-)	4.0	(-)	32.8	(-)	9.6	(-)
Slovenia	1182	(470)	55.6	(59.1)	6.2	(5.7)	1.9	(2.1)	32.7	(29.6)	3.6	(3.4)
Spain	1413	(102)	47.5	(56.9)	13.3	(5.9)	2.1	(2.9)	33.3	(31.4)	3.8	(2.9)
Total cases	74 993	(23 656)	45.8	(47.0)	10.1	(8.9)	1.5	(1.4)	35.9	(35.6)	6.8	(7.0)

¹Data for 69 CRs only are shown, as data for three cancer registries were not available (see text for further details).

²Not otherwise specified (NOS) morphology.

Table III. Age-standardised period relative survival estimates for patients followed up in 2000–2003. One-year, five-year relative survival and five-year conditional on surviving one-year relative survival and 95% confidence interval (CI), by country.

Country	1-year survival	95% CI	5-year survival	95% CI	5-year conditional survival	95% CI
Finland	74.6	(72.2–77.0)	43.4	(40.4–46.5)	58.2	(54.7–61.9)
Norway	75.6	(73.4–77.8)	41.7	(38.9–44.5)	55.2	(52.0–58.5)
Sweden	79.3	(77.6–81.0)	42.1	(39.9–44.3)	53.1	(50.6–55.6)
Ireland	60.7	(57.5–64.0)	29.1	(25.8–32.4)	47.9	(43.5–52.7)
UK England	60.7	(59.4–62.0)	30.0	(28.6–31.4)	49.5	(47.5–51.5)
UK Northern Ireland	62.9	(58.7–67.2)	35.5	(30.7–40.2)	56.4	(50.3–63.1)
UK Scotland	60.8	(58.5–63.2)	31.5	(29.1–34.0)	51.8	(48.5–55.4)
UK Wales	62.9	(59.8–66.0)	32.3	(29.1–35.5)	51.4	(47.2–55.8)
Austria	70.9	(68.9–72.9)	45.1	(42.7–47.5)	63.6	(60.8–66.5)
Germany	69.7	(64.4–74.9)	39.0	(31.7–46.4)	56.0	(47.3–66.4)
Netherlands	69.5	(66.3–72.7)	39.5	(35.8–43.2)	56.8	(52.5–61.5)
Switzerland	78.5	(74.3–82.7)	42.1	(36.4–47.7)	53.6	(47.5–60.5)
Czech Republic	64.9	(58.4–71.4)	38.6	(30.0–47.3)	59.6	(49.0–72.4)
Poland	66.4	(63.2–69.6)	37.8	(34.1–41.5)	56.9	(52.3–62.0)
Slovakia	56.1	(52.4–59.8)	25.3	(22.4–28.2)	45.1	(41.1–49.5)
Italy	69.6	(67.7–71.5)	37.1	(35.0–39.3)	53.3	(50.7–56.0)
Slovenia	68.8	(64.4–73.2)	36.7	(31.8–41.7)	53.4	(47.5–60.0)
Spain	63.6	(55.1–72.2)	37.2	(27.4–47.0)	58.5	(46.8–73.0)
European average	67.2	(66.6–67.8)	36.1	(35.4–36.8)	53.7	(52.8–54.6)

Table IV. Period relative survival estimates for patients followed up in 2000–2003 and 95% confidence interval (CI), by country and age.

Country	15–54	55–74	75–99
Finland	66.8	46.0	25.2
	(61.8–71.8)	(41.8–50.2)	(18.6–31.8)
Norway	64.8	46.0	20.8
	(60.0–69.6)	(41.6–50.4)	(15.6–26)
Sweden	57.5	42.8	30.0
	(53.7–61.3)	(39.8–45.8)	(25.2–34.8)
Ireland	50.8	31.4	13.0
	(44.6–57.0)	(26.4–36.4)	(7.0–19.0)
UK England	48.5	30.3	18.0
	(45.5–51.5)	(28.3–32.3)	(15.2–20.8)
UK Northern Ireland	51.6	40.7	15.5
	(43.0–60.2)	(33.5–47.9)	(7.3–23.7)
UK Scotland	53.0	30.9	17.4
	(47.6–58.4)	(27.5–34.3)	(13–21.8)
UK Wales	54.8	31.0	20.5
	(48.2–61.4)	(26.6–35.4)	(13.9–27.1)
Austria	73.5	47.8	23.7
	(69.7–77.3)	(44.4–51.2)	(18.9–28.5)
Germany	60.1	38.3	30.6
	(47.5–72.7)	(28.9–47.7)	(13.6–47.6)
Netherlands	61.9	40.6	23.3
	(55.5–68.3)	(35.4–45.8)	(15.7–30.9)
Switzerland	58.5	51.4	15.4
	(47.5–69.5)	(42.6–60.2)	(6.6–24.2)
Czech Republic	53.7	31.8	41.4
	(42.9–64.5)	(21.8–41.8)	(18.6–64.2)
Poland	54.4	40.8	21.8
	(49.2–59.6)	(36.0–45.6)	(12.8–30.8)
Slovakia	55.8	23.3	10.8
	(50.8–60.8)	(19.3–27.3)	(4.6–17.0)
Italy	68.1	36.4	19.0
	(64.1–72.1)	(33.2–39.6)	(15.0–23.0)
Slovenia	67.0	36.3	17.6
	(58.8–75.2)	(29.5–43.1)	(6.6–28.6)
Spain	69.9	31.6	23.6
	(52.9–86.9)	(18.2–45.0)	(4.8–42.4)
European average	58.6	37.1	20.5
	(57.4–59.8)	(36.1–38.1)	(19.1–21.9)

Table V. Period estimates for patients followed up in 2000–2003 of crude and age-standardised¹ five-year relative survival and 95% confidence interval (CI), by country and morphological groups.

	Crude					Age-standardised
Country	serous	mucinous	germ cell	other tumours	NOS^2	serous	mucinous	other tumours
Finland	47.6	64.8	83.4	52.4	26.4	43.1	55.0	48.5
	(43.2–52.0)	(56.4–73.2)	(67.0–99.8)	(46.0–58.8)	(17.2–35.6)	(38.6–47.7)	(44.2–65.9)	(41.6–55.3)
Norway	43.0	65.0	80.2	52.4	35.2	37.8	60.6	47.8
	(39.0–47.0)	(54.4–75.6)	(62.4–98.0)	(46.8–58.0)	(18.8–51.6)	(34.0–41.6)	(47.5–73.8)	(42.7–53.0)
Sweden	40.7	62.7	88.0	44.1	31.2	39.5	58.1	41.8
	(37.7–43.7)	(55.3–70.1)	(77.0–99.0)	(40.7–47.5)	(14.8–47.6)	(36.4–42.7)	(49.8–66.3)	(38.3–45.2)
Ireland	32.1	68.3	79.1	34.7	32.2	25.5	57.8	28.8
	(26.9–37.3)	(57.5–79.1)	(50.9–100.0)	(28.1–41.3)	(18.2–46.2)	(20.8–30.1)	(43.2–72.3)	(21.7–35.9)
UK England	36.4	54.8	84.6	31.4	11.5	34.7	51.9	29.1
	(34.0–38.8)	(49.4–60.2)	(74.2–95.0)	(29.0–33.8)	(7.3–15.7)	(31.9–37.4)	(45.5–58.3)	(26.8–31.5)
UK Northern Ireland	47.3	56.6	100.0	34.9	21.3	46.0	37.8	31.9
	(39.1–55.5)	(36.4–76.8)	(–)	(26.5–43.3)	(6.1–36.5)	(36.7–55.3)	(21.3–54.3)	(23.9–39.9)
UK Scotland	34.0	57.8	87.3	33.6	16.0	33.6	52.1	32.7
	(29.6–38.4)	(48.0–67.6)	(68.3–100.0)	(29.4–37.8)	(6.4–25.6)	(28.9–38.3)	(40.4–63.8)	(28.7–36.7)
UK Wales	35.4	55.4	52.3	28.5	22.3	33.8	56.1	27.0
	(28.2–42.6)	(40.6–70.2)	(0.0–100.0)	(22.3–34.7)	(12.5–32.1)	(26.1–41.5)	(39.2–73.0)	(20.9–33.2)
Austria	54.1	67.7	84.4	50.4	44.9	48.0	56.4	46.8
	(50.3–57.9)	(58.5–76.9)	(70.8–98.0)	(45.8–55.0)	(37.3–52.5)	(44.1–51.9)	(44.4–68.4)	(42.3–51.3)
Germany	40.4	65.9	^3)	48.0	17.6	39.8	^3)	40.7
	(31.0–49.8)	(35.3–96.5)		(32.2–63.8)	(0.6–34.6)	(30.2–49.5)		(24.8–56.5)
Netherlands	43.9	51.6	88.4	42.3	62.0	40.8	41.5	37.1
	(38.5–49.3)	(40.0–63.2)	(69.2–100.0)	(35.7–48.9)	(11.4–100.0)	(35.1–46.4)	(29.5–53.5)	(31.1–43.1)
Switzerland	49.8	45.0	100.0	42.1	^3)	46.4	^3)	38.8
	(41.6–58.0)	(22.8–67.2)	(–)	(30.9–53.3)		(38.6–54.3)		(28.1–49.5)
Czech Republic	48.1	45.3	0.0	40.8	^3)	33.6	^3)	^3)
	(36.3–59.9)	(21.5–69.1)	(0–0)	(29.6–52.0)		(24.1–43.2)
Poland	44.6	47.4	73.6	44.9	29.8	42.9	46.8	37.5
	(39.0–50.2)	(34.2–60.6)	(50.4–96.8)	(39.1–50.7)	(20.2–39.4)	(34.8–51.0)	(34.6–59.0)	(31.7–43.3)
Slovakia	33.9	51.4	100.0	33.7	30.9	23.9	35.4	25.7
	(29.7–38.1)	(41.8–61.0)	(–)	(27.5–39.9)	(9.1–52.7)	(19.8–28.0)	(25.1–45.7)	(20.2–31.2)
Italy	47.5	56.4	87.7	41.5	23.6	42.5	49.5	37.1
	(43.7–51.3)	(48.4–64.4)	(69.1–100.0)	(37.3–45.7)	(16.6–30.6)	(38.6–46.3)	(41.1–57.9)	(33.1–41.1)
Slovenia	44.5	44.1	90.3	42.8	33.6	37.6	^3)	36.0
	(37.5–51.5)	(22.9–65.3)	(69.1–100.0)	(33.6–52.0)	(4.4–62.8)	(29.8–45.4)		(28.0–44.0)
European average	41.8	58.5	85.6	39.8	26.1	38.1	51.9	36.3
	(40.8–42.8)	(56.1–60.9)	(81.2–90.0)	(38.6–41.0)	(23.5–28.7)	(36.9–39.3)	(49.0–54.9)	(35.1–37.6)

¹Age-standardisation was only applied for the three largest morphological groups.

²Not otherwise specified (NOS) morphology.

³Not enough cases in study to estimate survival.

Table VI. Time trend in age-standardised five-year relative survival and 95% confidence intervals (CIs), including 26¹ CRs, by country.

Country	1991–1993^2	1994–1996^2	1997–1999^2	2000–2003^3	Change^4
Finland	30.9	35.8	40.1	43.4	12.5
	(28.2–33.7)	(33.0–38.7)	(37.1–43.0)	(40.4–46.5)
Norway	34.4	34.9	38.9	41.7	7.3
	(31.5–37.2)	(32.2–37.7)	(36.1–41.7)	(38.9–44.5)
Sweden	37.9	40.8	43.3	42.1	4.2
	(35.8–40.1)	(38.7–43)	(40.9–45.6)	(39.9–44.3)
UK England	29.4	27.2	29.1	30.0	0.6
	(27.9–31)	(25.6–28.7)	(27.6–30.5)	(28.6–31.4)
UK Scotland	28.2	30.3	31.2	31.5	3.3
	(25.9–30.6)	(27.9–32.6)	(28.6–33.8)	(29.1–34.0)
UK Wales	29.8	30.6	31.3	32.3	2.5
	(26.3–33.3)	(27.2–34.0)	(28.2–34.5)	(29.1–35.5)
Austria	39.7	43.4	44.4	45.1	5.4
	(37.3–42.1)	(41.0–45.7)	(42.0–46.7)	(42.7–47.5)
Germany	37.4	35.2	33.9	39.0	1.6
	(31–43.8)	(29.1–41.2)	(27.8–39.9)	(31.7–46.4)
Netherlands	33.5	33.7	34.8	38.0	4.5
	(29.6–37.5)	(29.8–37.7)	(30.7–38.9)	(33.4–42.5)
Switzerland	30.4	38.0	42.7	40.9	10.5
	(25–35.8)	(31.7–44.4)	(36.6–48.8)	(34.5–47.3)
Czech Republic	24.4	27.1	^5)	38.6	14.2
	(18.3–30.5)	(20.0–34.2)		(30.0–47.3)
Poland	26.7	28.0	33.8	38.1	11.4
	(22.4–31)	(24.6–31.4)	(29.6–37.9)	(33.6–42.6)
Slovakia	28.4	28.3	29.0	25.3	–3.1
	(24.2–32.5)	(24.3–32.2)	(25.5–32.6)	(22.4–28.2)
Italy	31.9	35.1	34.3	37.2	5.3
	(28.8–35.1)	(32.1–38.1)	(31.3–37.3)	(34.2–40.1)
Slovenia	26.7	33.1	35.4	36.7	10
	(22–31.5)	(26.6–39.6)	(30.3–40.5)	(31.8–41.7)
European average	32.4	33.8	35.4	36.3	3.9
	(31.7–33.2)	(33.0–34.6)	(34.6–36.2)	(35.5–37.0)

¹26 CRs provided continuous incident data in 1991–2002 for trend analyses (see text for further details).

²Survival estimated using the cohort approach.

³Survival estimated for patients followed up in 2000–2003 using the period hybrid approach.

⁴Absolute difference in percent points between the estimates for 2000–2003 and 1991–1993.

⁵Not enough cases to estimate survival.

Table VII. Time trend in five-year relative survival and 95% confidence intervals (CIs) including 26¹ CRs, by age.

	1991–1993^2	1994–1996^2	1997–1999^2	2000–2003^3	Change^4
15–54	55.1	57.0	58.3	58.6	3.5
	(53.7–56.5)	(55.6–58.4)	(56.9–59.7)	(57.2–60.0)
55–74	31.8	33.2	35.3	37.1	5.3
	(30.8–32.8)	(32.2–34.2)	(34.3–36.3)	(36.1–38.1)
75–99	19.8	20.4	21.3	21.0	1.2
	(18.2–21.4)	(18.8–22.0)	(19.7–22.9)	(19.4–22.6)
15–99	37.3	38.7	39.9	40.3	3.0
	(36.5–38.1)	(37.9–39.5)	(39.1–40.7)	(39.5–41.1)

¹26 CRs provided continuous incident data in 1991–2002 for trend analyses (see text for further details).

²Survival estimated using the cohort approach.

³Survival estimated for patients followed up in 2000–2003 using the period hybrid approach.

⁴Absolute difference in percent points between the estimates for 2000–2003 and 1991–1993.