Clinical outcomes of image guided radiation therapy (IGRT) with gold fiducial vaginal cuff markers for high-risk endometrial cancer

Figures & data

Table I. Patient characteristics.

Stage:
Ib	1
II	8
IIIA	3
IIIC1	8
IIIC2	4
IV	2
Grade:
I	1
II	10
III	15
Karnofsky performance status:
100	17
90	7
80	2
Angio-lymphatic invasion:
Yes	16
No	10
Chemotherapy:
None	9
Taxol/Adriamycin/Cisplatin	5
Carboplatin/Taxol	9
Combination	3
Median age:	62 years
Median tumor size:	4 cm
Median myometrial invasion:	65%
Median external beam dose:	47.50 Gy

Figure 1. Daily translation magnitude.

Figure 2. a) Sample coronal dose distribution at the level of the vaginal cuff fiducials. b) Dose-volume histogram for sample patient.

Table II. Univariate analysis.

	GU toxicity		GI toxicity
Predictor	Grade 2	Grade 0–1	Grade 2–3	Grade 0–1
Hypertension
Yes	2	9	4	7
No	1	14	5	10
Stage
I-II	1	8	1	8
III-IV	2	15	8	9
Prior abdominal surgery
Yes	2	6	3	5
No	1	17	6	12
Extended field
Yes	1	4	3	5
No	2	19	6	15
Brachytherapy
Yes	3	8	2	9
No	0	15	7	8
Chemotherapy
Yes	2	15	8	9
No	1	8	1	8
Rectal V40
Mean/median	n/a	n/a	63.3/55.0*	35.9/35.0*
Bowel V40
Mean/median	n/a	n/a	30.0/24.0	17.8/22.0
Bladder V45
Mean/median	46.3/34.0	48.4/44.0	n/a	n/a
Age (years)
Mean/median	65.0/59.0	62.0/62.0	61.9/61.0	62.6/65.0
Weight (kg)
Mean/median	64.5/74.5	79.0/76.8	77.2/66.8	77.7/76.8
Nodes Dissected
Mean/median	24.7/25.0	21.9/19.0	22.8/25.0	21.9/20.0

*p= 0.007; all other values not statistically significant.