Figures & data
Table I. Principal component analysis of DVH parameters.
Table II. Univariate analysis of patient demographic and tumor characteristics and dose-volume factors, by RP grade (N = 176).
Table III. Multivariate logistic regression analysis of factors associated with RP.
Table IV. RP-related dose-volume variables in patients with grade ≥ 2 or grade ≥ 3 RP, corrected for age.
Table V. Comparison of RP rate by cut point of dose-volume variables (age ≥ 70) (n = 65).
Table VI. Comparison of RP rate by cut point of dose-volume variables (age<70) (n = 111).
Table VII. Study comparison of RP.
Barriger RB, Fakiris AJ, Hanna N, Yu M, Mantravadi P, Mcgarry RC. Dose-volume analysis of radiation pneumonitis in non-small-cell lung cancer patients treated with concurrent cisplatinum and etoposide with or without consolidation docetaxel. Int J Radiat Oncol Biol Phys 2010;78:1381–6. Parashar B, Edward A, Mehta R, Pasmantier M, Wernicke AG, Sabbas A, et al. Chemotherapy significantly increases the risk of radiation pneumonitis in radiation therapy of advanced lung cancer. Am J Clin Oncol 2011;34:160–4. Dang J, Li G, Lu XB, Yao L, Zhang S, Yu Z. Analysis of related factors associated with radiation pneumonitis in patients with locally advanced non-small-cell lung cancer treated with three-dimensional conformal radiotherapy. J Cancer Res Clin Oncol 2010;136:1169–78. Jin H, Tucker SL, Liu HH, Wei X, Yom SS, Wang S, et al. Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy. Radiother Oncol 2009;91:427–32. Fay M, Tan A, Fisher R, Mac Manus M, Wirth A, Ball D. Dose-volume histogram analysis as predictor of radiation pneumonitis in primary lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys 2005;61:1355–63. Shi A, Zhu G, Wu H, Yu R, Li F, Xu B. Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy. Radiat Oncol 2010;12:35. Kimura T, Togami T, Takashima H, Nishiyama Y, Ohkawa M, Nagata Y. Radiation pneumonitis in patients with lung and mediastinal tumours: A retrospective study of risk factors focused on pulmonary emphysema. Br J Radiol 2012;85: 135–41. Wang S, Liao Z, Wei X, Liu H, Tucker S, Hu C, et al. Analysis of clinical and dosimetric factors associated with treatment-related pneumonitis (TRP) in patients with non-small-cell lung cancer (NSCLC) treated with concurrent chemotherapy and three-dimensional conformal radiotherapy (3D-CRT). Int J Radiat Oncol Biol Phys 2006;66:1399–407. Kim TH, Cho KH, Pyo HR, Lee JS, Han JY, Zo JI, et al. Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimensional conformal radiation therapy for lung cancer. Radiology 2005;235:208–15. Robnett TJ, Machtay M, Vines EF, McKenna MG, Algazy KM, McKenna WG. Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 2000;48: 89–94.