Time trends in population-based breast cancer survival in Estonia: Analysis by age and stage

Figures & data

Figure 1. Female breast cancer incidence and mortality in Estonia (age-standardized to world standard population), 1995–2010.

Table I. Distribution of cases by age at diagnosis, stage at diagnosis and period of diagnosis: women diagnosed with breast cancer in Estonia, 1995–2007.

			1995–1999		2000–2004		2005–2007
	No	%	No	%	No	%	No	%
Total	7424	100.0	2678	100.0	2925	100.0	1821	100.0
Microscopic confirmation	7105	95.7	2515	93.9	2819	96.4	1771	97.3
Age at diagnosis
< 50	1683	22.7	699	26.1	614	21.0	370	20.3
50–59	1859	25.0	632	23.6	756	25.8	471	25.9
60–69	1823	24.6	680	25.4	744	25.4	399	21.9
70+	2059	27.7	667	24.9	811	27.7	581	31.9
Stage^a
Localized	2914	39.3	917	34.2	1213	41.5	784	43.1
Local/regional spread	3401	45.8	1210	45.2	1347	46.1	844	46.3
Distant	769	10.4	332	12.4	300	10.2	137	7.5
Unknown	340	4.5	219	8.2	65	2.2	56	3.1
Tumor size
T1	2100	28.3	577	21.5	882	30.2	641	35.2
T2	2946	39.7	1035	38.6	1237	42.3	674	37.0
T3	442	6.0	174	6.5	153	5.2	115	6.3
T4	1224	16.5	541	20.2	478	16.3	205	11.3
T not available	712	9.6	351	13.1	175	6.0	186	10.2

^aLocalised: T1–3 N0 M0; Local/regional spread: T1–3 N1–3 M0 or T4 Nany M0; Distant: Tany Nany M1.

Figure 2. Percentage of cases diagnosed at localized stage among all breast cancer cases in Estonia by age at diagnosis, 1995–2007.

Figure 3. Age-standardized cumulative relative survival from breast cancer in Estonia, 1995–2009. Cohort estimates for 1995–1999, 2000–2004 and 2005–2007, period estimates for 2005–2009.

Figure 4. Stage-specific cumulative relative survival from breast cancer in Estonia, 1995–2009. Cohort estimates for 1995–1999 and 2000–2004, period estimates for 2005–2009.

Table II. Relative survival from breast cancer in Estonia, 1995–2009.

	1995–1999 cohort estimate				2000–2004 cohort estimate			2005–2009 period estimate
	1-year RSR	5-year RSR	95% CI	10-year RSR	1-year RSR	5-year RSR	95% CI	1-year RSR	5-year RSR	95% CI	10-year RSR	Diff 5-year^a	Diff 10-year^a
Total	89.6	64.4	62.2–66.4	54.0	91.6	73.5	71.5–75.4	92.6	75.9	74.0–77.8	66.2	11.5	12.2
Age-standardized^b	87.2	62.5	59.5–62.3	49.8	89.8	70.9	68.3–73.4	91.3	73.5	71.0–75.9	63.1	11.0	13.3
Age at diagnosis (years)
< 50	95.0	67.5	63.8–71.0	57.4	95.1	78.1	74.5–81.3	96.6	81.6	78.2–84.6	73.0	14.1	15.6
50–59	91.4	65.4	61.3–69.2	57.1	94.6	78.3	74.9–81.3	94.5	80.7	77.5–83.5	72.1	15.3	15.0
60–69	89.1	67.2	63.1–71.1	55.7	91.8	71.0	67.2–74.6	93.5	75.2	71.4–78.7	64.6	8.0	8.9
70+	82.4	56.7	51.4–62.0	46.8	85.7	67.1	62.2–71.8	87.0	67.5	62.9–72.0	56.3	10.8	9.5
Stage^c
Localized	99.8	90.8	87.9–93.5	82.5	99.6	95.1	92.7–97.2	100.1	96.1	93.9–98.1	89.9	5.3	7.4
T1 N0 M0^d	99.3	95.1	91.0–98.3	90.4	99.3	99.1	96.3–101.4	99.9	100.1	97.5–102.1	98.1	5.0	7.7
T2–3 N0 M0^d	100.1	87.7	83.3–91.5	76.2	99.8	91.1	87.2–94.6	100.3	92.0	88.0–95.5	82.0	4.3	5.8
Local/ regional spread	92.9	59.2	56.1–62.3	46.1	94.4	68.5	65.6–71.3	94.2	70.3	67.5–73.1	58.0	11.1	11.9
T1–3 N1–3 M0^d	97.5	68.3	64.5–71.9	54.6	97.0	76.1	72.8–79.2	96.9	78.9	75.7–81.9	65.7	10.6	11.1
T4 Nany M0^d	82.0	37.6	31.9–43.4	26.4	87.2	46.5	40.0–52.9	84.1	42.7	36.1–49.3	32.8	5.1	5.4
Distant	49.8	7.8	5.0–11.3	2.7	47.7	12.2	8.6–16.6	46.7	10.6	7.0–14.9	3.9	2.8	1.2
Unknown	88.5	66.0	58.2–73.1	54.3	87.2	52.1	37.0–66.6	75.6	46.1	32.6–59.8	31.5

^aDifference between the RSRs of 2005–2009 and 1995–1999; ^bICSS standard population 1; ^cLocalized: T1–3 N0 M0; Local/regional spread: T1–3 N1–3 M0 or T4 Nany M0; Distant: Tany Nany M1; ^dOnly cases with known T included.

Table III. Five-year relative survival from breast cancer by stage, tumor size and age in Estonia, 2005–2009.

Stage at diagnosis^a	Tumor size	Age at diagnosis	5-year RSR	95% CI
Localized	All	< 50	96.0	92.4–98.1
		50–59	96.3	93.1–98.5
		60–69	96.0	91.5–99.3
		70+	96.0	88.8–102.3
	T1	< 50	98.0	93.4–99.9
		50–59	98.1	94.4–100.3
		60–69	100.7	95.2–103.9
		70+	106.0	95.8–113.9
	T2–3	< 50	93.0	85.8–96.9
		50–59	95.9	89.4–99.4
		60–69	91.1	83.3–96.6
		70+	88.7	78.4–97.7
Local/regional spread	All	< 50	76.8	71.5–81.2
		50–59	74.2	69.1–78.8
		60–69	70.6	64.7–75.8
		70+	60.6	53.8–67.2
	T1–3	< 50	84.3	78.7–88.6
		50–59	82.8	77.2–87.4
		60–69	77.5	70.8–83.2
		70+	70.6	62.0–78.5
	T4	< 50	49.9	34.1–63.9
		50–59	46.5	31.8–60.2
		60–69	44.1	31.6–56.2
		70+	37.4	26.6–49.1
Distant	All	< 50	13.3	4.2–27.9
		50–59	15.3	7.1–26.5
		60–69	10.7	4.8–19.4
		70+	7.0	2.9–13.8

^aLocalized: T1–3 N0 M0; Local/regional spread: T1–3 N1–3 M0 or T4 Nany M0; Distant: Tany Nany M1.

Table IV. Age-adjusted period estimates of five-year relative survival from breast cancer.

Country (region)	Period	Overall RSR	Localized		Local/regional spread		Distant
			%^a	RSR	%^a	RSR	%^a	RSR
Estonia	2005–2009	74	44	96	48	67	8	11
Germany (Saarland)^b	2005–2008	83	50	99	42	79	8	24
US (SEER-13 registries)^b	2005–2008	88	63	97	31	83	6	27

^aproportion among cases with available stage; ^bFrom Holleczek and Brenner, 2012 [15].

Holleczek B, Brenner H. Trends of population-based breast cancer survival in Germany and the US: Decreasing discrepancies, but persistent survival gap of elderly patients in Germany. BMC Cancer 2012;12:317.

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