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ORIGINAL ARTICLES

Survival and tumour control probability in tumours with heterogeneous oxygenation: A comparison between the linear-quadratic and the universal survival curve models for high doses

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Pages 1035-1040 | Received 22 Apr 2014, Accepted 14 May 2014, Published online: 24 Jun 2014

Figures & data

Figure 1. Simple models of tumour oxygenation: (a) uniformly oxic tumour with OER = 1, (b) uniformly anoxic tumour with OER = 3, and (c) partly hypoxic tumour with 20% hypoxia (OER = 3).

Figure 1. Simple models of tumour oxygenation: (a) uniformly oxic tumour with OER = 1, (b) uniformly anoxic tumour with OER = 3, and (c) partly hypoxic tumour with 20% hypoxia (OER = 3).

Figure 2. Survival curves obtained with the LQ (solid curves) and USC (dashed curves) models. Red curves represent a uniformly oxic tumour with OER = 1, blue curves represent a uniformly anoxic tumour with OER = 3, and purple curves represent an intermediate case of a partly hypoxic tumour with 80% OER = 1 and 20% OER = 3.

Figure 2. Survival curves obtained with the LQ (solid curves) and USC (dashed curves) models. Red curves represent a uniformly oxic tumour with OER = 1, blue curves represent a uniformly anoxic tumour with OER = 3, and purple curves represent an intermediate case of a partly hypoxic tumour with 80% OER = 1 and 20% OER = 3.

Figure 3. Dose-response curves for the various fractionation schedules as a function of total dose delivered to a tumour with 1.1% hypoxic fraction. Calculations have been done based on both the LQ model (solid curves) and the USC model (dashed curves).

Figure 3. Dose-response curves for the various fractionation schedules as a function of total dose delivered to a tumour with 1.1% hypoxic fraction. Calculations have been done based on both the LQ model (solid curves) and the USC model (dashed curves).
Supplemental material

http://informahealthcare.com/doi/abs/10.3109/0284186X.2014.925582

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