Figures & data
Table I. Patient's characteristics for all patients and for the three groups separately.
Table II. Rectal dose volume constraints per group. For patients in Group 3, two separate sets of dose volume constraints were applied. One to prevent late grade ≥ 2 and one to prevent late grade 1 rectal toxicity, respectively. Following planning strategy was routinely used in the treatment planning of patients in Group 3: start of the planning with initial implementation of rectal volume constraints to prevent grade ≥ 2 late rectal toxicity. If these constraints were easily met, a second optimisation was performed in order to lower the rectal dose further and, if possible, to meet the criteria for preventing late grade 1 rectal toxicity.
Table III. Incidence of late grade 1–3 rectal toxicity for the three groups separately at different time points after the end of radiotherapy based on analysis of all patients. χ2 statistics were calculated. Percentages are reported between brackets. Groups between which statistical significant differences at a certain time point were found are added.
Table IV. Three-year actuarial risk of developing late rectal toxicity per group. Data are presented as percentages. p-Values were calculated by log-rank analysis.
Table V. Incidence of late grade 1–3 urinary toxicity for the three groups separately at different time points after the end of radiotherapy for patients treated in the primary and postoperative setting. χ2 statistics were calculated. Percentages are reported between brackets. Groups between which statistical significant differences at a certain time point were found are added.
Table VI. Three-year actuarial risk of developing late urinary toxicity per group both in the primary and postoperative setting. Data are presented as percentages. p-Values were calculated by log-rank analysis.