Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients

Figures & data

Table I. Serum concentrations of DcR3 in different diseases.

Diseases	DcR3 serum level (pg/mL)	DcR3 expression rate	P compared with
			Cirrhosis	Cholecystitis	Healthy controls
HCC	197.07 ± 90.34	51/67 (76%)	0.094	0.002	0.005
Cirrhosis	179.81 ± 102.74	5/8 (62%)	—	0.083	0.003
Cholecystitis	101.59 ± 24.51	3/17 (18%)	—	—	0.102
Healthy controls	96.69 ± 16.05	1/28 (4%)	—	—	—

Table II. Relationship between serum DcR3 concentrations and clinicopathological parameters in hepatocellular carcinoma (HCC).

HCC clinicopathological parameters		Serum DcR3 level (pg/mL)	Serum DcR3 expression rate	P
Age	≥50	207.90 ± 82.76	25/30 (83%)	0.212
	<50	189.76 ± 95.44	26/37 (70%)
Gender	male	206.18 ± 92.69	47/58 (81%)	0.048
	female	138.35 ± 40.37	4/9 (44%)
HBV	positive	221.34 ± 64.34	45/51 (88%)	0.296
	negative	198.14 ± 45.13	6/16 (38%)
HCV	positive	208.73 ± 45.63	8/10 (80%)	0.187
	negative	178.63 ± 61.04	43/57 (75%)
Differentiation	well and moderately	187.89 ± 88.45	41/53 (77%)	0.106
	poorly	231.84 ± 92.13	10/14 (71%)
Clinical TNM stage	I–II	160.76 ± 62.57	26/37 (70%)	0.014
	III–IV	224.78 ± 98.85	25/30 (83%)
Para-cirrhosis	yes	212.76 ± 92.60	37/44 (84%)	0.005
	no	150.94 ± 66.11	14/23 (61%)
Tumor capsular infiltration	no capsular or capsular infiltration	219.52 ± 95.59	32/37 (86%)	0.015
	no capsular infiltration	167.66 ± 74.70	19/30 (63%)
Portal vein tumor embolus	yes	198.26 ± 84.80	9/11 (82%)	0.944
	no	196.56 ± 93.48	42/56 (75%)
Tumor nodes	multi	207.34 ± 94.55	20/25 (80%)	0.477
	single	190.96 ± 88.33	31/42 (74%)
Tumor size (cm)	≥5	207.05 ± 89.54	35/43 (81%)	0.304
	<5	184.00 ± 91.26	16/24 (67%)
AFP (μg/L)	≥400	213.10 ± 90.42	23/28 (82%)	0.327
	<400	185.56 ± 89.66	28/39 (72%)
Metastasis or recurrence	yes	215.04 ± 93.63	34/40 (85%)	0.02
	no	164.88 ± 75.66	17/27 (63%)

Figure 1. Expression of DcR3 protein in hepatocellular carcinoma tissues. DcR3 protein was detected by immunohistochemistry in hepatocellular carcinoma (HCC) tissues. (A: DcR3 negative; B: positive+; C: ++; D: +++). The signal was localized within the cytoplasm of tumor cells in HCC tissues (×400).

Table III. Correlation between the level of serum DcR3 and the expression of DcR3 protein in hepatocellular carcinoma (HCC) tissues.

		Expression of DcR3 protein in HCC tissues
Level of serum DcR3 (pg/mL)	n	-	+	++	+++
Negative (0–122.22)	15	11	4	0	0
Low level (122.23–149.99)	16	6	5	4	1
Moderate level (150.00–299.99)	20	6	8	4	2
High level (≥300.00)	13	2	4	2	5