Platelet kinetics after slow versus standard transfusions: A pilot study

Figures & data

Table I. Responses to treatment in relation to the patients' basic diagnoses.

	Slow transfusion		Standard transfusion
Diagnosis	Frequency (%)	Ref. (n)	Frequency (%)	Ref. (n)
ALL	7 (53.8)	1	6 (46.2)	0
AML	5 (35.7)	1	9 (64.3)	1
Aplastic anemia	6 (50)	1	6 (50)	2
Pancytopenia	3 (60)	1	2 (40)	0
Lymphoma	6 (100)	1	0	0
Multiple myeloma	0	0	1 (100)	0
CML	0	0	4 (100)	1
Myeloproliferative dis.	1 (100)	0	0	0

Ref. = refractoriness (defined as cases with low platelet count 1 hour following transfusion).

Table II. Platelet count (×10⁹/L) (in the two groups) following transfusion.

	Transfusion
	Slow	Standard	P value	MD	CI 95%
Prior to infusion	10.5 ± 5.1	14.0 ± 8.2	0.064	-3.44	-7.09	0.20
1 hour following infusion	30.9 ± 16.8	47.5 ± 29.0	0.011	-16.65	-29.30	-4.00
24 hours following infusion	35.0 ± 26.4	41.2 ± 29.6	0.423	-6.20	-21.63	9.22
1 week after infusion	48.5 ± 68.8	33.8 ± 21.9	0.355	14.76	-17.56	47.09

MD = mean difference; CI 95% = confidence interval 95%.

Figure 1. Platelet count (×10 ⁹/L) following standard (broken lines) or slow (full lines) transfusion in males (A) and females (B).