Electrocardiographic P-wave characteristics in patients with psoriasis vulgaris

Figures & data

Table I. Disease-specific characteristics of patients with psoriasis vulgaris.

	Mean ± SD
Mean age of onset of psoriasis (years ± SD)	20.1 ± 7.7 (range: 9–35)
Mean duration of disease (years ± SD)	12.8 ± 7.0 (range: 3–26)
Mean PASI score	3.5 ± 3.7 (range: 0.4–16.8)
Mean PSI score	1.6 ± 0.9 (range: 0–3)
Mean Affected BSA (%)	6.2 ± 14.5 (range: 0–90)
Mean NAPSI score	21.4 ± 25.2 (range: 0–93)
% of patients with nail involvement	75.6 (31/41)

BSA = body surface area; NAPSI = Nail Psoriasis Severity Index; PASI = Psoriasis Area and Severity Index; PSI = Psoriasis Severity Index; SD = standard deviation.

Figure 1. Bland–Altman plots demonstrating the 95% limits of agreement between (A) the repeated measurements of PWD by the same observer and (B) between the manual and digital measurements of PWD by two different observers, in 30 randomly selected patients.

Table II. Demographic characteristics of the study population. Data were presented as mean ± standard deviation.

	Group 1 (Psoriatic) (n = 61)	Group 2 (Control) (n = 58)	P
Age (years)	33.3 ± 6.7	35.0 ± 6.4	NS
Male gender (%)	34 (55.7%)	35 (60.3%)	NS
Current smoker (%)	42.6 (26/61)	34.5 (20/58)	NS
Family history of CAD (%)	16.4 (10/61)	15.5 (9/58)	NS
BMI (kg/m^2)	25.7 ± 3.4	26.0 ± 2.6	NS
Waist circumference (cm)	95.4 ± 8.2	93.5 ± 7.9	NS
Office SBP (mmHg)	118.9 ± 10.6	119.1 ± 10.5	NS
Office DBP (mmHg)	73.8 ± 8.7	73.5 ± 10.6	NS
HR (bpm)	80.5 ± 9.9	83.1 ± 11.5	NS
Fasting glucose (mg/dL)	89.2 ± 10.1	92.3 ± 12.7	NS
Serum LDL cholesterol (mg/dL)	114.6 ± 35.3	117.7 ± 25.7	NS
Serum triglycerides (mg/dL)	113.7 ± 51.4	126.1 ± 60.1	NS
HsCRP (mg/L)	1.3 ± 0.3	0.3 ± 0.3	0.001

BMI = body mass index; CAD = coronary artery disease; DBP = diastolic blood pressure; HR = heart rate; HsCRP = high-sensitivity C-reactive protein; LDL = low-density lipoprotein; NS = statistically non-significant; SBP = systolic blood pressure.

Table III. Echocardiographic measurements of study population. Data were presented as mean ± standard deviation.

	Group 1 (n = 61)	Group 2 (n = 58)	P
2D echocardiography
LVESD (cm)	3.6 ± 0.5	3.5 ± 0.7	NS
LVEDD (cm)	4.9 ± 0.4	5.1 ± 0.5	NS
LV Ejection fraction (%)	62.6 ± 4.4	63.2 ± 3.6	NS
LA (cm)	3.7 ± 0.2	3.8 ± 0.3	NS
Doppler echocardiography
E (cm/s)	81.7 ± 18.8	83.2 ± 16.1	NS
A (cm/s)	61.1 ± 14.3	63.4 ± 16.0	NS
EDT (ms)	162.8 ± 51.4	167.7 ± 48.9	NS
IRT (ms)	83.3 ± 14.5	84.7 ± 12.9	NS

A = the peak mitral valve flow velocity during atrial contraction; E = the peak mitral valve flow velocity during the early rapid filling phase; EDT= deceleration time of early phase of mitral valve flow; IRT = isovolumetric relaxation time; LA = left atrial diameter; LV = left ventricle; LVEDD = left ventricle end-diastolic diameter; LVESD = left ventricle end-systolic diameter.

Table IV. Comparison of P-wave values of the groups. Data were presented as mean ± standard deviation.

	Group 1 (n = 61)	Group 2 (n = 58)	P
Pmax (ms)	112.6 ± 22.7	93.0 ± 12.8	<0.001
Pmin (ms)	42.2 ± 12.5	47.4 ± 14.3	0.04
PWD (ms)	69.1 ± 22.6	45.6 ± 19.4	<0.001

Pmax = maximum P-wave duration; Pmin = minimum P-wave duration; PWD = P-wave dispersion.

Figure 2. Scatter plot of the PASI score against PWD (ms) (r = 0.367, P = 0.005).