Hb J-Wenchang-Wuming [α11(A9)Lys→Gln (AAG>CAG) (α2 or α1)] Compromises Neonatal Screening for α-Thalassemia with the Sebia Capillarys2 Electrophoresis System

Abstract

We describe a Chinese newborn who was assumed to have α⁰-thalassemia (α⁰-thal) by determining the amount of Hb Bart’s (γ4) in the cord blood, but was later shown to have only α⁺-thal. Hb J-Wenchang-Wuming [α11(A9)Lys→Gln (AAG>CAG) (α2 or α1)] was mistaken for Hb Bart’s as both hemoglobin (Hb) variants have the same mobility.

• α-Thalassemia (α-thal)
• Newborn screening
• Hb Bart’s (γ4)
• Capillary electrophoresis