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Cancer Investigation Volume 28, 2010 - Issue 10
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ORIGINAL ARTICLEClinical Translational Therapeutics

Obesity and Microvascular Invasion in Hepatocellular Carcinoma

Abby B. SiegelDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New YorkCorrespondence[email protected]
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Shuang WangDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Judith S. JacobsonDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Dawn L. HershmanDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Emerson A. LimDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Jeanette YuDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Lauren FerranteDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Kalpana M. DevarajDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Helen RemottiDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Shannon ScrudatoDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Karim HalazunDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Jean EmondDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Lorna DoveDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Robert S. Brown JrDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Alfred I. NeugutDepartment of Medicine, Columbia University, New York, Department of Biostatistics, Columbia University, New York, Department of Epidemiology, Columbia University, New York, Department of Pathology and Cell Biology, Columbia University, New York, Department of Surgery, Columbia University, New York, Department of Medicine and Pediatrics, Columbia University, New York, Division of Oncology, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University, New York
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Pages 1063-1069 | Published online: 15 Nov 2010
 
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ABSTRACT

Background: We hypothesized that hepatocellular carcinoma (HCC) patients with higher Body Mass Index (BMI) might have more microvascular invasion (MVI) in their tumors. Methods: Records from 138 consecutive patients who underwent surgery at Columbia University Medical Center from January 1, 2002 to January 9, 2008 were evaluated. Results: 40 patients (29%) had MVI, including 14% with BMI <25, 31% with BMI = 25–30, and 40% with BMI >30 (p = .05). However, only maximum alpha-fetoprotein was significantly associated with overall mortality in a Cox model. Conclusions: MVI was associated with obesity. A better understanding of the mechanism of this association may lead to interventions for the treatment and prevention of HCC.

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