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Cancer Investigation Volume 30, 2012 - Issue 9
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CLINICAL TRANSLATIONAL THERAPEUTICS

Increased Rab25 Expression is not Correlated With Peritoneal Metastasis of Ovarian Cancers

Min ZhaoWuxi Maternity and Children Health Hospital Affiliated Nanjing Medical University, China,
,
Yong Xiang YinWuxi Maternity and Children Health Hospital Affiliated Nanjing Medical University, China,Correspondence[email protected]
,
Fang GuoThe Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China,
,
You Yi YangWuxi Maternity and Children Health Hospital Affiliated Nanjing Medical University, China,
,
Fang ShenThe Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China,
&
Qi Chen
Pages 683-687 | Published online: 02 Oct 2012
 
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Abstract

Ovarian cancer is the leading cause of death in gynecological cancer. Studies suggested Rab25 is involved in the pathogenesis of ovarian cancers. We here investigated the expression of Rab25 is in all ovarian cancers and whether the expression of Rab25 is associated with peritoneal metastasis. Fifty-nine ovarian cancer patients were included and the levels of Rab25 measured by immunohistochemistry. Our data showed Rab25 was highly expressed in all subtypes of epithelial ovarian cancers, and two subtypes of germ cell tumors, but not in sex cord stromal tumors. Furthermore, the Rab25 expression was not correlated with peritoneal metastasis of ovarian cancer.

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