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Cancer Investigation Volume 33, 2015 - Issue 4
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ORIGINAL ARTICLES

ERCC1 SNPs as Potential Predictive Biomarkers in Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

Aristea KalikakiLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece
,
Alexandra VoutsinaLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, GreeceCorrespondence[email protected]
,
Anastasios KoutsopoulosDepartment of Pathology
,
Chara PapadakiLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece
,
Maria SfakianakiLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece
,
Emmanouel YachnakisLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece
,
Alexandros XyrafasLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece
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Athanasios KotsakisLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece;Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece
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Sofia AgelakiLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece;Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece
,
John SouglakosLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece;Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece
,
Dimitrios MavroudisLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece;Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece
&
Vassilis GeorgouliasLaboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece;Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete, Greece
 show all
Pages 107-113 | Received 06 Aug 2014, Accepted 19 Dec 2014, Published online: 03 Feb 2015
 
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Abstract

Polymorphisms in ERCC1, XPD, and XRCC1 were examined for (a) association with the clinical outcome of 107 non-small cell lung cancer patients receiving front-line platinum-based chemotherapy, and (b) correlation with the ERCC1 mRNA levels of 176 chemo-naive primary tumors. The ERCC1-C8092 allele and the number of ERCC1 polymorphic variants (C8092A and Asn118Asn) were associated with progression-free survival. In non-squamous histology, tumoral ERCC1 mRNA levels were lower in patients homozygous for ERCC1-C8092 as compared with the patients carrying the A allele (p = .024). These findings merit investigation in larger cohorts of patients treated with uniform regimens.

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