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Cancer Investigation Volume 32, 2014 - Issue 6
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Original Article

External Beam Radiotherapy ± Chemotherapy in the Treatment of Anal Canal Cancer: A Single-Institute Long-Term Experience on 100 Patients

Berardino De BariCorrespondence[email protected]
,
Michela BuglioneDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
,
Marta MaddaloDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
,
Laëtitia LestradeDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
,
Luigi SpiazziDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
,
Paola VitaliDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
,
Fernando BarberaDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
&
Stefano M. MagriniDepartment of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia, Brescia, Italy
 show all
Pages 248-255 | Received 18 Jul 2013, Accepted 18 Mar 2014, Published online: 25 Apr 2014
 
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Abstract

One-hundred patients treated with curative radiotherapy (RT) ± chemotherapy (CT) for an anal canal carcinoma (T1–4N0–3M0) were retrospectively analyzed. Five- and 10-year local control (LC) rates were 73% and 67%, respectively. Acute and late G3–G4 toxicity rates were 32% and 12%, respectively. Two patients underwent a colostomy for a G4 anal toxicity. This study confirms the outcomes of RT ± CT in the treatment of anal canal cancer. Concomitant CT and LC statistically influenced Overall Survival and Colostomy-Free Survival. CT also statistically reduced the risk of nodal relapse. High rates of acute skin toxicity impose tailored volumes and techniques of irradiation.

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