Advanced search
Publication Cover
Cancer Investigation Volume 32, 2014 - Issue 6
Submit an article Journal homepage
303
Views
33
CrossRef citations to date
0
Altmetric
Original Article

B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression

Feifei Wang
,
Guoyan WangDepartment of Clinical Laboratory, the Yantai Affiliated Hospital of Binzhou Medical University, Yantai, P.R. China,
,
Tongshen LiuDepartment of Immunology, Binzhou Medical University, Yantai, P.R. China,
,
Guohua YuDepartment of Pathology, Yuhuangding Hospital, Yantai, P.R. China,
,
Guangbo ZhangClinical Immunology Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou, P.R. China
&
Xiying LuanDepartment of Immunology, Binzhou Medical University, Yantai, P.R. China,Correspondence[email protected]
Pages 262-271 | Received 28 Aug 2013, Accepted 26 Mar 2014, Published online: 30 Apr 2014
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

B7-H3 has been detected in different cancers and correlated to tumor progression and outcome in cancer patients. In this study, we investigated the expression of B7-H3 in tissues and cells of primary hepatocellular carcinoma (PHC) patients. The research showed that B7-H3 is aberrantly expressed in PHC tissues and cells, and its high expression on HepG2 cells significantly promotes cell proliferation, adhesion, migration, and invasion capacity; moreover, it inhibits the proliferation of CD8+ T cells. Thus, B7-H3 may have a critical role in PHC and it may enhance tumor escape from the immune surveillance of CD8+ T cells.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.