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Cancer Investigation Volume 34, 2016 - Issue 2
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Original Articles

Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas

Emad ElquzaDivision of Hematology and Oncology, University of Arizona Cancer Center, Tucson, AZ, USA
,
Hani M. BabikerDivision of Hematology and Oncology, University of Arizona Cancer Center, Tucson, AZ, USACorrespondence[email protected]
,
Krisha J. HowellDepartment of Radiation Oncology, University of Arizona, Tucson, AZ, USA
,
Andrew I. KovoorDepartment of Medicine, University of Arizona, Tucson, AZ, USA
,
Thomas David BrownSwedish Cancer Institute, Seattle, WA, USA
,
Hitendra PatelDivision of Hematology and Oncology, University of Arizona Cancer Center, Tucson, AZ, USA
,
Steven A. MalangoneDivision of Hematology and Oncology, University of Arizona Cancer Center, Tucson, AZ, USA
,
Mitesh J. BoradDivision of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, USA
&
Tomislav DragovichBanner MD Anderson Cancer Center, Gilbert, AZ, USA
 show all
Pages 57-63 | Received 04 Jun 2015, Accepted 11 Oct 2015, Published online: 25 Jan 2016
 
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ABSTRACT

Purpose: To establish the maximum tolerated dose (MTD) and safety profile of bi-weekly Pemetrexed (PEM) when combined with weekly cisplatin (CDDP) and standard dose external beam radiation (EBRT) in patients with locally advanced or metastatic esophageal and gastroesophageal junction (GEJ) carcinomas. Methods: We conducted an open label, single institution, phase I dose escalation study designed to evaluate up to 15–35 patients with advanced or metastatic esophageal and GEJ carcinomas. Results: 10 patients were treated with bi-weekly PEM, weekly CDDP, and EBRT. The MTD of bi-weekly PEM was determined to be 500 mg/m2.

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