Prostate cancer mortality in Taiwanese men: Increasing age-standardized trend in general population and increased risk in diabetic men

Figures & data

Figure 1. Flow chart showing the procedures in the calculation of mortality from prostate cancer in the diabetic cohorts.

Figure 2. Secular trends of prostate cancer mortality in the Taiwanese male general population from 1995 to 2006.

Table I. The mortality rate (per 100,000) from prostate cancer and overall mortality rate (per 100,000) from all-causes by age in the Taiwanese male general population in 1995–2006 and the average mortality rate within this 12-year period.

Age (years)	Prostate and overall MR in general population	1995	1996	1997	1998	1999	2000	2001	2002	2003	2004	2005	2006	Average	P^a
40–64	n of PC	35	34	47	46	29	61	60	44	48	40	56	60	47
	MYP	2576753	2654115	2737115	2831340	2933998	3037988	3142535	3246734	3350715	3452074	3546682	3640548	3095883
	MR from PC	1.4	1.3	1.7	1.6	1.0	2.0	1.9	1.4	1.4	1.2	1.6	1.6	1.5	0.7948
	Overall MR	810.7	804.7	769.9	751.7	737.2	719.8	708.4	683.1	678.3	686.5	701.9	684.3	723.5	<0.0001
65–74	n of PC	119	163	166	173	167	174	184	201	174	198	214	204	178
	MYP	633594	651416	661022	666575	668093	663768	654953	646223	638278	631604	628407	629220	647763
	MR from PC	18.8	25.0	25.1	26.0	25.0	26.2	28.1	31.1	27.3	31.3	34.1	32.4	27.5	<0.0001
	Overall MR	3156.1	3105.7	3041.4	3002.2	3004.8	2959.2	2999.3	2896.5	2867.6	2844.7	2811.4	2653.4	2946.8	<0.0001
≥ 75	n of PC	216	266	317	321	365	399	449	505	520	581	639	691	439
	MYP	239815	256536	275487	295092	315060	338169	363853	389650	415976	438526	466054	488446	356889
	MR from PC	90.1	103.7	115.1	108.8	115.9	118.0	123.4	129.6	125.0	132.5	137.1	141.5	123.0	<0.0001
	Overall MR	8869.8	8824.9	8258.5	8331.6	8199.7	7902.9	7755.6	7555.8	7479.8	7600.0	7681.5	7162.1	7861.7	<0.0001

MR = mortality rate; MYP = mid-year population; PC = prostate cancer.

^aThe trend tested by linear regression.

Table II. Age-specific mortality rates (per 100,000 person-years) from prostate cancer in the diabetic male patients and the mortality rate ratios comparing diabetic male patients to the average mortality rates in the Taiwanese male general population.

Age (years)	n	N	Person-year	Mortality rate	Mortality rate ratio
I. Original cohort analysis
Followed from enrollment to end of 2006
40–64	51	60278	494704.5	10.31	6.84 (5.34–8.75)
65–74	156	30704	211811.1	73.65	2.68 (2.29–3.13)
≥ 75	114	11669	59761.6	190.76	1.55 (1.29–1.86)
Followed from enrollment to end of 2000
40–64	19	60278	203137.2	9.35	6.21 (4.16–9.25)
65–74	53	30704	94488.8	56.09	2.04 (1.56–2.66)
≥ 75	58	11669	30353.6	191.08	1.55 (1.20–2.01)
Followed from 2001 to end of 2006
40–64	22	48431	267973.6	8.21	5.45 (3.73–7.96)
65–74	75	26548	133463.8	56.19	2.04 (1.63–2.56)
≥ 75	94	13653	59608.3	157.70	1.28 (1.05–1.57)
II. Subcohort diabetic men analyses
Diabetes of any duration at enrollment
40–64	17	23958	167823.3	10.13	6.72 (4.43–10.19)
65–74	58	12395	76349.6	75.97	2.76 (2.15–3.55)
≥ 75	33	3574	17710.4	186.33	1.51 (1.08–2.13)
Diabetes duration < 10 years at enrollment
40–64	14	18376	131755.2	10.63	7.05 (4.47–11.11)
65–74	38	7887	49825.0	76.27	2.77 (2.04–3.77)
≥ 75	18	2138	10946.7	164.43	1.34 (0.84–2.12)
Diabetes duration ≥ 10 years at enrollment
40–64	3	5582	36070.3	8.32	5.52 (2.01–15.11)
65–74	20	4508	26541.7	75.35	2.74 (1.80–4.18)
≥ 75	15	1436	6785.4	221.06	1.80 (1.09–2.96)
III. Subcohort type 2 diabetic men analyses
Diabetes of any duration at enrollment
40–64	16	23197	162814.6	9.83	6.52 (4.24–10.03)
65–74	56	12051	74413.3	75.26	2.74 (2.12–3.53)
≥ 75	33	3448	17171.3	192.18	1.56 (1.11–2.19)
Diabetes duration < 10 years at enrollment
40–64	13	17991	129175.8	10.06	6.68 (4.15–10.74)
65–74	37	7742	48999.2	75.51	2.75 (2.01–3.75)
≥ 75	18	2088	10708.6	168.09	1.37 (0.86–2.17)
Diabetes duration ≥ 10 years at enrollment
40–64	3	5206	33638.1	8.92	5.92 (2.18–16.05)
65–74	19	4309	25428.1	74.72	2.72 (1.76–4.19)
≥ 75	15	1360	6484.3	231.33	1.88 (1.14–3.10)

n = number of prostate cancer.