Figures & data
Figure 1. MiRNome analysis for circulating microRNAs in migraine. Schematic representation of circulating microRNAs as modulated by migraine. The x-axis indicates fold change in expression level on a log10 scale as compared to control subjects.
![Figure 1. MiRNome analysis for circulating microRNAs in migraine. Schematic representation of circulating microRNAs as modulated by migraine. The x-axis indicates fold change in expression level on a log10 scale as compared to control subjects.](/cms/asset/04db2c62-cae2-4ae6-9679-3daa2d19fc35/iann_a_1071871_f0001_b.gif)
Figure 2. Validation of circulating microRNAs expression on individual plasma samples by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. * q < 0.05; ** q < 0.01; *** q < 0.001 (probability values corrected for multiple comparison by the Benjamini–Hochberg FDR method; n = 13 for control subjects, n = 15 for migraine patients).
![Figure 2. Validation of circulating microRNAs expression on individual plasma samples by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. * q < 0.05; ** q < 0.01; *** q < 0.001 (probability values corrected for multiple comparison by the Benjamini–Hochberg FDR method; n = 13 for control subjects, n = 15 for migraine patients).](/cms/asset/bd8277e2-4809-472f-ab6a-e7cf5b6b90eb/iann_a_1071871_f0002_b.gif)
Figure 3. Receiver-operating characteristic (ROC) curve derived from the logistic regression model developed with circulating let-7b, miR-22, miR-27b, and miR-181a as predictors. AUC = area under curve.
![Figure 3. Receiver-operating characteristic (ROC) curve derived from the logistic regression model developed with circulating let-7b, miR-22, miR-27b, and miR-181a as predictors. AUC = area under curve.](/cms/asset/c484d20e-4bec-41da-8427-3085422f94ef/iann_a_1071871_f0003_b.gif)
Figure 4. Expression of microRNAs in peripheral blood mononuclear cells (PBMCs) assessed by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. *P < 0.05; ** P < 0.01; *** P < 0.001 (n = 13 for control subjects, n = 15 for migraine patients).
![Figure 4. Expression of microRNAs in peripheral blood mononuclear cells (PBMCs) assessed by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. *P < 0.05; ** P < 0.01; *** P < 0.001 (n = 13 for control subjects, n = 15 for migraine patients).](/cms/asset/76a9b9fe-7c9f-4743-85de-0bdd33e02dfe/iann_a_1071871_f0004_b.gif)