The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives

Figures & data

Table I. Comparison of ambulatory blood pressure monitoring resuls between dippers and non-dippers.

	Non-dippers (n=28)	Dippers (n=28)	p-value
Daytime SBP, mmHg	144.2±9.9	140.8±8.5	0.47
Daytime DBP, mmHg	89.9±9.2	87.0±9.0	0.39
Night-time SBP, mmHg	137.1±11.0	120.2±8.0	<0.001
Night-time DBP, mmHg	85.3±8.0	72.8±7.9	<0.001
24-h SBP, mmHg	141.5±10.2	132.3±7.7	<0.001
24-h DBP, mmHg	88.2±8.5	81.0±8.2	<0.01
24-h Average BP, mmHg	105.7±8.5	97.7±7.4	<0.001

SBP, systolic blood pressure; DBP, diastolic blood pressure; BP, blood pressure.

Table II. Characteristics, blood pressure, and laboratory parameters of study groups.

	Non-dippers (n=28)	Dippers (n=28)	Normotensives (n=27)
Men/women	11/17	10/18	16/11
Age, years	53±10	51±8	51±4
Clinic SBP, mmHg	148.2±29.2*	144.4±49.3*	116.8±9.7
Clinic DBP, mmHg	94.4±11.0*	92.1± 11.3*	65.3±9.2
Fasting glucose, mg/dl	81.9±7.13	79.3±6.3	79±6.5
Creatinine, mg/dl	0,84±0,14	0.84±0.19	0.78±0.14
Total cholesterol, mg/dl	202.2±33.0*	209.5±42.8*	179.0±16.5
LDL-cholesterol, mg/dl	129.4±26.0*	142.5±33.8*	111.7±14.9
HDL-cholesterol, mg/dl	43.5±10.8**	37.1±10.2	42.1±5.4
Triglyceride, mg/dl	136.5±56.0	151.3±82.5	116.8±9.7
Body mass index, kg/m^2	28.4±4.4*	29.5±4.8*	25.8±2.1
MPV, fl	9,61 ±0,42*‘**	9,24±0,35*	8,87 ±0,33
Hs-CRP, mg/1	4.8±1.4*‘**	3.6±1.6	2.4±0.9
Platelet count, 10^3/μl	308.1±119.9	291.5±95.9	333.8±90.2
Medications
ACE inh. use, %	16, 57%	15, 54%	–
ARB use, %	4, 14%	6, 21%	–
Beta-blocker use, %	6, 21%	8, 29%	–
Ca-channel blocker use, %	4, 14%	7, 25%	–
Diuretic use, %	13, 46%	15, 54%	–

SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein; MPV, mean platelet volume; Hs-CRP, C-reactive protein; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker. *p<0.05 non-dippers and dippers vs normotensives. **p<0.05 non-dippers vs dippers.

Figure 1. Comparison of mean platelet volume (MPV) levels in non-dippers compared with dippers and controls.

Figure 2. Correlations between mean platelet volume (MPV) and ambulatory diastolic (A) and systolic (B) blood pressure.