Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients

Figures & data

Table I. Clinical characteristics and laboratory findings of study population.

Variable
Male/female	46/34
Age, years	53 ± 5
Body mass index, kg/m^2	24.5 ± 3. 0
Clinic SBP, mmHg	176.5 ± 10.0
Clinic DBP, mmHg	108.5 ± 10.5
24-h SBP, mmHg	145.8 ± 10.2
24-h DBP, mmHg	95.5 ± 5.5
Dipper/non-dipper	56/84
Fasting glucose, mg/dl	65.2 ± 6.3
Creatinine, mg/dl	0.72 ± 0.56
Total cholesterol, mg/dl	190.1 ± 30.9
LDL-cholesterol, mg/dl	118 ± 18.0
HDL-cholesterol, mg/dl	42 ± 9.5
Triglyceride, mg/dl	149.8 ± 36.8
Hemoglobin, mg/dl	14.8 ± 2.3
Platelet count, 10^3/μl	330 ± 23
MPV, fl	9.2 ± 0.52
UACR, mg/mmol	0.54 ± 0.05
LVMI, g/m^2	111.4 ± 25.8
Carotid IMT, mm	0.95 ± 0.20
Hs-CRP, mg/lt	4.2 ± 1.2

Data are expressed as mean ± standard deviation. SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein; MPV, mean platelet volume; UACR, urinary albumin–creatinine ratio; LVMI, left ventricular mass index; IMT, intima media thickness; Hs-CRP, high-sensitivity C reactive protein.

Figure 1. Correlation between mean platelet volume (MPV) levels and ambulatory blood pressure measurements. SBP-24 h, 24-h systolic blood pressure; DBP-24 h, 24-h diastolic blood pressure.

Figure 2. Correlation between mean platelet volume (MPV) levels and high-sensitivity C reactive protein (hs-CRP), urinary albumin–creatinine ratio (UACR), left ventricular mass index (LVMI) and carotid intima media thickness (IMT).

Table II. Multiple linear regression analyses: Relationship between urinary albumin–creatinine ratio (UACR), carotid intima media thickness (IMT), left ventricular mass index (LVMI) and selected variables.

Variable	Coefficient	p-value
Dependent variable: UACR
24-h SBP	0.45	0.001
24-h DBP	0.39	0.001
MPV	0.48	0.001
BMI	0.28	0.12
hs-CRP	0.42	0.001
Dependent variable: carotid IMT
24-h SBP	0.38	0.02
24-h DBP	0.36	0.03
MPV	0.49	0.001
BMI	0.25	0.12
hs-CRP	0.48	0.001
Dependent variable: LVMI
24-h SBP	0.45	0.001
24-h DBP	0.42	0.001
MPV	0.48	0.001
BMI	0.20	0.18
hs-CRP	0.28	0.08

SBP, systolic blood pressure; DBP, diastolic blood pressure; MPV, mean platelet volume; BMI, body mass index; Hs-CRP, high-sensitivity C reactive protein.