Association between asymmetric dimethylarginine and indices of vascular function in patients with essential hypertension

Figures & data

Table I. Baseline characteristics of the study subjects.

Variable	Hypertension patients (n = 80)
Age (years)	47 ± 10
Weight (kg)	79.5 ± 11.9
Height (cm)	172.2 ± 9.4
Body mass index (kg/m^2)	26.7 ± 2.5
Waist-to-hip ratio	0.89 ± 0.08
Smokers (%)	12.5
Brachial SBP (mmHg)	145.4 ± 11.9
Brachial DBP (mmHg)	90.3 ± 7.6
Brachial PP (mmHg)	55.1 ± 10.7
Central SBP (mmHg)	131.4 ± 17.9
Central DBP (mmHg)	84.8 ± 9
Central PP (mmHg)	46.6 ± 13.4
Heart rate (beats/min)	69 ± 9.1
Augmentation index (%)	23.2 ± 13.4
AIx@75 (%)	19.2 ± 12.8
Timing for reflection (ms)	146.8 ± 13.7
Aortic PWV (m/s)	7.4 ± 1.4
IMT (mm)	0.8 ± 0.1
Total cholesterol (mmol/l)	5.3 ± 0.87
LDL-cholesterol (mmol/l)	3.4 ± 0.8
HDL-cholesterol (mmol/l)	1.7 ± 0.6
Triglycerides (mmol/l)	1 (0.8; 1.5)
ADMA (μmol/l)	0.6 ± 0.2
Glucose (mmol/l)	5.2 ± 0.6
Creatinine (mmol/l)	68.6 ± 12.9
hsCRP (mmol/l)	0.9 (0.5; 2.1)
eGFR (ml/min/1.73 m^2)	102.8 ± 17.2

Normally distributed data are presented as mean ± SD; non-normally distributed data are presented as the median with the interquartile range. SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; AIx@75, augmentation index at a heart rate of 75; PWV, pulse wave velocity; IMT, carotid intima-media thickness; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ADMA, asymmetric dimethylarginine; hsCRP, high-sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate.

Figure 1. Correlation between asymmetric dimethylarginine (ADMA) and endothelium-dependent vasodilation (EDV).

Figure 2. Correlation between asymmetric dimethylarginine (ADMA) and carotid intima-media thickness (IMT).

Table II. Results of multiple regression analysis with asymmetric dimethylarginine (ADMA) as the dependent variable.

Variables	Regression coefficient	Standard error	p-value
IMT (mm)	0.53	0.15	0.001
EDV (%)	−0.01	0.004	0.02
Total cholesterol (mmol/l)	−0.06	0.02	0.008
Gender (female)	0.07	0.04	0.05
Smoking status	−0.09	0.05	0.08

R² = 0.30; p < 0.001. IMT, carotid intima-media thickness; EDV, endothelium-dependent vasodilation.