Circulating immune complexes correlate with collagen carboxypropeptide in patients with essential hypertension

Figures & data

Table I. Demographic data.

	EH group	Control group	EH vs control
Cases (male/female)	121 (63/58)	30 (15/15)	p >0.05
Age (years)	55.63 ± 9.92	56.73 ± 10.34	p > 0.05
BMI (kg/m^2)	27.73 ± 5.28	24.38 ± 4.35	p < 0.05
SBP (mmHg)	161 ± 26	119 ± 10	p < 0.01
DBP (mmHg)	88 ± 23	76 ± 6	p <0.05
Cholesterol (mmol/l)	4.68 ± 0.71	4.36 ± 0.62	p >0.05
LDL-C (mmol/l)	2.83 ± 0.58	2.56 ± 0.65	p >0.05
HDL-C (mmol/l)	1.30 ± 0.49	1.44 ± 0.43	p >0.05
IgG (mg/dl)	1280 ± 251	1054 ± 276	p <0.01

The data are presented by mean ± SD. EH, essential hypertension; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL-C, low-density lipoprotein-cholesterol; HDL, high-density lipoprotein-cholesterol; IgG, immunoglobulin G.

Figure 1. Plasma levels of circulating immune complex (CIC), von Willebrand factor (vWF), high-sensitivity C-reactive protein (Hs-CRP) and type I collagen carboxypropeptide (TICP). Blood samples were collected from 121 essential hypertension (EH) patients and 30 healthy subjects and analyzed by enzyme-linked immunosorbent assay (ELISA). Bars indicate the plasma levels of (A) CIC, (B) vWF and (C) TICP. Data were presented as mean ± SD. *p < 0.01, compared with healthy subjects.

Table II. Serum cytokine levels.

	IL-4	IL-6	IL-10	IL-1-β	IFN-γ	TNF-α
Healthy	4.0 ± 1.3	5.3 ± 2.1	38.2 ± 8.2	19.5 ± 5.1	2.9 ± 1.1	2.1 ± 1.0
EH	5.1 ± 1.5	26.2 ± 1.6	56.6 ± 9.2	21.5 ± 5.5	3.2 ± 1.3	1.9 ± 0.8
P	> 0.05	< 0.05	< 0.05	> 0.05	> 0.05	> 0.05

IL, interleukin; IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α; EH, essential hypertension.