The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension

Figures & data

Table I. Baseline demographic, clinical and biochemical characteristics of patients.

Variables	DM (n = 21)	HT (n = 30)	HT and DM (n = 50)	p
Age (years)	54.71 ± 7.96	56.47 ± 7.15	57.82 ± 5.88	0.204
Gender (M/F)	5/16	14/16	16/34	0.206
Smoking	6	11	16	0.823
SBP (mmHg)	126.95 ± 7.17	132.07 ± 8.87	134.4 ± 5.75	0.001
DBP (mmHg)	78.57 ± 3.94	80.80 ± 6.32	80.32 ± 5.63	0.346
PP (mmHg)	48.38 ± 7.88	51.27 ± 8.56	54.08 ± 6.85	0.015
Pulse (beats/min)	79.19 ± 6.59	78.37 ± 5.05	79.20 ± 4.64	0.766
BMI (kg/m²)	31.76 ± 3.14	31.80 ± 2.86	31.36 ± 2.75	0.758
TC (mg/dl)	210.38 ± 29.17	200.50 ± 25.05	202.88 ± 27.90	0.429
LDL-C (mg/dl)	120.52 ± 13.67	115.37 ± 12.32	116.50 ± 13.38	0.374
HDL-C (mg/dl)	41.42 ± 3.76	40.03 ± 3.09	40.23 ± 3.42	0.309
TG (mg/dl)	238.02 ± 59.76	233.07 ± 63.43	230.49 ± 52.28	0.880
Creatinine (mg/dl)	0.81 ± 0.18	0.83 ± 0.21	0.80 ± 0.23	0.303
Hyaluronidase,(mU/L)	3032.33 ± 345.07	3059.73 ± 272.22	3135.96 ± 344.59	0.959
NO (μM/L)	39.33 ± 2.96	40.00 ± 3.41	39.94 ± 3.71	0.275

Data are shown as mean± SD. DM, diabetes mellitus; HT, hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; BMI, body mass index; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglyceride; NO, nitric oxide.

Patients with both DM and HT had statistically higher levels of SBP and PP in comparison to patients with DM but not HT. Bold values indicate statistical significance (p < 0.05).

Figure 1. The correlation between serum hyaluronidase and nitric oxide (NO) levels in all patients.

Figure 2. The correlation between serum hyaluronidase and nitric oxide (NO) levels in only diabetic patients.

Figure 3. The correlation between serum hyaluronidase and nitric oxide (NO) levels in hypertensive patients.

Figure 4. The correlation between serum hyaluronidase and nitric oxide (NO) levels in hypertensive and diabetic patients.

Table II. The relation of serum hyaluronidase and nitric oxide levels with parameters of aortic elasticity including aortic strain, aortic strain index and aortic distensibility.

	Hyaluronidase levels		NO levels
	r	p	r	p
DM
Aortic strain	− 0.703	< 0.001	0.647	0.002
Aortic strain index	0.750	< 0.001	− 0.525	0.014
Aortic distensibility	− 0.650	0.001	0.640	0.002
HT
Aortic strain	− 0.426	0.019	0.309	0.096
Aortic strain index	0.497	0.005	− 0.442	0.014
Aortic distensibility	− 0.362	0.049	0.217	0.250
HT and DM
Aortic strain	− 0.572	< 0.001	0.379	0.007
Aortic strain index	0.480	< 0.001	− 0.400	0.004
Aortic distensibility	− 0.482	< 0.001	0.296	0.037

DM, diabetes mellitus; HT, hypertension.