Abstract
Objective: The goal of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to ovarian cancer.
Methods: Meta-analyses were conducted on the associations between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and ovarian cancer.
Results: A total of 12 comparison studies were considered in the meta-analysis, which involved 3716 patients and 5059 controls. Meta-analysis of the VDR FokI polymorphism showed an association between ovarian cancer and the f allele in European populations (OR = 1.094, 95% CI = 1.028–1.163, p = 0.004). Meta-analysis revealed an association between ovarian cancer and the ApaI A allele in all study subjects and Europeans as a sub-group (OR = 1.235, 95% CI = 1.019–1.497, p = 0.032 and OR = 1.287, 95% CI = 1.029–1.609, p = 0.027, respectively). No association was found between ovarian cancer and the BsmI and Taq polymorphisms (OR for B allele = 1.084, 95% CI = 0.936–1.255, p = 0.280, OR for the T allele = OR = 0.847, 95% CI = 0.706–1.270, p = 0.716).
Conclusions: This meta-analysis suggests that the VDR FokI and ApaI polymorphisms are associated with susceptibility to ovarian cancer in European populations.
Declaration of interests
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The authors have no financial or non-financial conflict of interest to declare.
The authors alone are responsible for the content and writing of the paper.