Translating the Low Translaminar Cribrosa Pressure Gradient Hypothesis into the Clinical Care of Glaucoma

ABSTRACT

Glaucoma is an optic neuropathy with multiple known risk factors, including age, race, family history, and intraocular pressure. Unfortunately, the only currently modifiable risk factor in treating the disease is intraocular pressure (IOP). Recent studies have investigated intracranial pressure (ICP) and the translaminar cribrosa pressure gradient as a potential explanation for glaucomatous optic nerve vulnerability across a range of IOP values. The difference between these two pressures across the lamina cribrosa may have an effect on the optic nerve, which could provide another modifiable parameter in the battle against glaucoma. In order for modification of the translaminar pressure gradient to be considered in the treatment of glaucoma, noninvasive methods to accurately measure ICP need to be developed. The translaminar pressure gradient could be therapeutically adjusted by either further lowering the IOP or raising the ICP when it is pathologically low, if possible.

• Intracranial pressure
• intraocular pressure
• primary open angle glaucoma

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

No author has any financial interests in the material discussed here. Drs. Pasquale and Wiggs are supported by the Glaucoma Center of Excellence. Dr. Pasquale is also supported by a Harvard Medical School Ophthalmology Scholar award.