Cancer Testis Antigens: Novel Biomarkers and Targetable Proteins for Ovarian Cancer

Figures & data

TABLE I  Principal Characteristics of OC Correlated with Disease Stage

STAGE 1	The cancer is still contained within the ovary(ies)
STAGE 2	The cancer is in the ovary(ies) but spreading to other organs in the pelvis (uterus, fallopian tubes, bladder)
STAGE 3	The cancer is in the ovary(ies) and has spread beyond the pelvis and/or to lymph nodes
STAGE 4	The cancer is in the ovary(ies), but metastases are discovered in different organs outside the pelvis and peritoneal cavity, such as the liver and lungs (with cells in pleural fluid)

TABLE II  Expression of the Nine Most Reliable CTAs Compared with CA125 in OC

	ELISA	RT-PCR	IHC	Northern blot
SPAG9	67%	90%	—	—
OY-TES	10%	69%	69%	—
Piwil2	—	75%	—	—
LAGE-1	25%	21%	43%	—
NY-ESO-1	25%	43%	43%	—
Sp17	—	83%	—	68%
SSX	2.27%	26%	—	—
AKAP-3	—	58%	—	—
HOM-TES-14 (SCP-1)	0%	15%	0%	—
CA125 [89]	78%	—	70%	—

—: No data available.