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International Reviews of Immunology Volume 31, 2012 - Issue 5
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Research Article

Cancer Testis Antigens: A Novel Target in Lung Cancer

Maurizio Chiriva-InternatiCorrespondence[email protected]
,
Apurva PandeyDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Radhi SabaDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Minji KimDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Charles SaadehDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Tiajani LukmanDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
,
Raffaella ChiaramonteDepartment of Health Science, Università degli Studi di Milano, Italy
,
Marjorie Jenkins
,
Everardo Cobos
,
Cynthia JumperDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
&
Read AlalawiDepartment of Internal Medicine, Division of Hematology & Oncology and Pulmonary and Critical Care Medicine, The Southwest Cancer Treatment and Research Center, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
 show all
Pages 321-343 | Published online: 19 Oct 2012
 
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Abstract

Lung cancer is the main cause of cancer mortality worldwide. This is mainly due to the fact that it is diagnosed in advanced stage patients, which are no more surgically curable. Consequently, searching for novel treatments and new modalities for early diagnosis offers great promise to improve the clinical outcome. Recently, a new group of antigens, the cancer testis antigens, have been described as possible early diagnostic tools and therapeutic targets in cancer therapy.This review will report emerging evidences of cancer testis antigens deregulation in lung cancer and explore the state of the art of their currently known role and potential as markers for early diagnosis and disease progression and targets of an immunotherapeutic approach aiming to improve the cure rate of this tumor.

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