FIGURE 1. Renal biopsy specimen showed massive clear-cell transformation of the tubules; glomeruli showed a diffuse mesangial matrix increase and a thickening of basement membrane. It is also associated with tubular interstitial fibrosis (trichrome stain × 40).
FIGURE 2. Proximal tubular cells are massively swollen with small vacuoles and nuclei are displaced toward the base of the cells in addition to isometric vacuolization (trichrome stain × 400).
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