Urinary UMOD Excretion and Chronic Kidney Disease in Gout Patients: Cross-Sectional Case–Control Study

Figures & data

Figure 1. Pearson correlation of eGFR (mL/min per 1.73 m²) and urinary UMOD/UCR ratio (mg/g) in 53 patients with gout (Ha: ρ > 0, p = 0.004).

Table 1. Comparison of demographic data, age, urinary UMOD excretion, serum uric acid, serum creatinine, and eGFR in gout patients with and without CKD

Patient characteristics	Non-CKD	CKD	Crude odds ratio (95% CI)	p-Value
Gender N (%)
Male	26 (49.1)	23 (43.4)	1.130 (0.147–8.696)	1
Female	2 (3.8)	2 (3.8)
Hypertension N (%)
Yes	10 (18.9)	15 (28.3)	2.7 (0.888–8.214)	0.102
No	18 (34)	10 (18.9)
Diabetes mellitus N (%)
Yes	1 (1.9)	3 (5.7)	3.682 (0.357–37.922)	0.333
No	27 (50.9)	22 (41.5)
Smoking N (%)
Yes	2 (3.8)	2 (3.8)	1.13 (0.147–8.682)	1
No	26 (49.1)	23 (43.4)
Age (years)
Mean ± SD	43.93 ± 12.95	60.76 ± 12.59		<0.001
Serum uric acid (mg/dL)
Mean ± SD	7.55 ± 1.82	8.5 ± 1.47		0.042
Urinary UMOD/UCR (mg/g)
Mean ± SD	6.70 ± 5.46	4.15 ± 4.86		0.08

Table 2. Multivariate analysis using a stepwise logistic regression model to predict variables associated with CKD in gout patients

Predictor variables	Adjusted odds ratio (95% CI)	p-Value
Age (years)	1.139 (1.05–1.236)	<0.001
Urinary UMOD/UCR	0.826 (0.694–0.985)	<0.001
Serum uric acid	1.991 (1.107–3.582)	<0.001
Hypertension	0.778 (0.153–3.973)	0.763
Diabetes mellitus	15.247 (0.002–97,090.121)	0.542
Smoking	0.403 (0.025–6.592)	0.524